One-pot synthesis of reactive oxygen species (ROS)-self-immolative polyoxalate prodrug nanoparticles for hormone dependent cancer therapy with minimized side effects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00473654" target="_blank" >RIV/61389013:_____/17:00473654 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C7PY00270J" target="_blank" >http://dx.doi.org/10.1039/C7PY00270J</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C7PY00270J" target="_blank" >10.1039/C7PY00270J</a>
Alternative languages
Result language
angličtina
Original language name
One-pot synthesis of reactive oxygen species (ROS)-self-immolative polyoxalate prodrug nanoparticles for hormone dependent cancer therapy with minimized side effects
Original language description
A new reactive oxygen species (ROS)-sensitive, self-immolative biodegradable polyoxalate prodrug based on the anticancer chemotherapeutic hormone analog diethylstilbestrol was synthesized via one-pot step-growth polymerization. The nanoparticles prepared from this prodrug undergo self-immolative degradation releasing the chemotherapeutic drug in ROS-rich environments, e.g., in cancer cells. This new ROS self-immolative polyprodrug backbone eliminates the need for a linker between polymer chain and drug, resulting in a more specific drug release and minimized toxic side effects to non-ROS-producing cells as proven by in vitro experiments. The strategy enables re-utilization of a successful chemotherapeutic agent that has been clinically under-utilized due to dose-related side effects.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Chemistry
ISSN
1759-9954
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
13
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
1999-2004
UT code for WoS article
000398993800002
EID of the result in the Scopus database
2-s2.0-85016285630