„Schizophrenic” micelles from doubly thermoresponsive polysulfobetaine-b-poly(N-isopropylmethacrylamide) diblock copolymers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00474828" target="_blank" >RIV/61389013:_____/17:00474828 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.macromol.7b00356" target="_blank" >http://dx.doi.org/10.1021/acs.macromol.7b00356</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.7b00356" target="_blank" >10.1021/acs.macromol.7b00356</a>
Alternative languages
Result language
angličtina
Original language name
„Schizophrenic” micelles from doubly thermoresponsive polysulfobetaine-b-poly(N-isopropylmethacrylamide) diblock copolymers
Original language description
The 2-fold thermoresponsive diblock copolymer PSPP498-b-PNIPMAM144, which consists of a zwitterionic polysulfobetaine (PSPP) block and a nonionic poly(N-isopropylmethacrylamide) (PNIPMAM) block, is prepared by consecutive RAFT polymerizations. It combines the upper and lower critical solution temperature (UCST and LCST) behaviors, respectively, of the constitutive homopolymers in aqueous solution. We investigate the temperature-dependent phase behavior and the self-assembled structures of the block copolymer in D2O by turbidimetry and by small-angle neutron scattering (SANS) in salt-free solution and in the presence of small amounts of NaCl and NaBr. For comparison, solutions of PNIPMAM homopolymer in D2O are studied as well. Turbidimetry indicates thermally induced “schizophrenic” aggregation behavior for PSPP498-b-PNIPMAM144. SANS reveals that conventional star-like core–shell micellar structures are formed above the LCST transition, whereas below the UCST-transition, structure formation is much less pronounced. This is attributed to the different types of interactions, namely hydrophobic and ionic ones, dominating in the different regimes. Despite the increased polarity contrast between the zwitterionic and the nonionic blocks, and the much wider separation of the UCST- and LCST-based cloud points, CPUCST and CPLCST, the structural features of the new PSPP498-b-PNIPMAM144 resemble the ones found previously for the also 2-fold thermoresponsive analogue PSPP432-b-PNIPAM200, for which both phase transition temperatures nearly coincide. Remarkably, the addition of small amounts of NaBr or NaCl to the solution of PSPP498-b-PNIPMAM144 causes a significant increase of CPUCST, as well as minor but notable changes in the self–assembled structures, but no gross alterations of the phase behavior.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GC15-10527J" target="_blank" >GC15-10527J: Spherical „horse in vacuum“ or applicable micelles? Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecules
ISSN
0024-9297
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
3985-3999
UT code for WoS article
000402498100024
EID of the result in the Scopus database
2-s2.0-85019927518