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Nanoparticle-cell interactions: surface chemistry effects on the cellular uptake of biocompatible block copolymer assemblies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00487151" target="_blank" >RIV/61389013:_____/18:00487151 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1021/acs.langmuir.7b04040" target="_blank" >http://dx.doi.org/10.1021/acs.langmuir.7b04040</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acs.langmuir.7b04040" target="_blank" >10.1021/acs.langmuir.7b04040</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Nanoparticle-cell interactions: surface chemistry effects on the cellular uptake of biocompatible block copolymer assemblies

  • Original language description

    The development of nanovehicles for intracellular drug delivery is strongly bound to the understating and control of nanoparticles cellular uptake process, which in turn is governed by surface chemistry. In this study, we explored the synthesis, characterization, and cellular uptake of block copolymer assemblies consisting of a pH-responsive poly[2-(diisopropylamino)ethyl methacrylate] (PDPA) core stabilized by three different biocompatible hydrophilic shells (a zwitterionic type poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) layer, a highly hydrated poly(ethylene oxide) (PEO) layer with stealth effect, and an also proven nontoxic and nonimmunogenic poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) layer). All particles had a spherical core–shell structure. The largest particles with the thickest hydrophilic stabilizing shell obtained from PMPC40-b-PDPA70 were internalized to a higher level than those smaller in size and stabilized by PEO or PHPMA and produced from PEO122-b-PDPA43 or PHPMA64-b-PDPA72, respectively. Such a behavior was confirmed among different cell lines, with assemblies being internalized to a higher degree in cancer (HeLa) as compared to healthy (Telo-RF) cells. This fact was mainly attributed to the stronger binding of PMPC to cell membranes. Therefore, cellular uptake of nanoparticles at the sub-100 nm size range may be chiefly governed by the chemical nature of the stabilizing layer rather than particles size and/or shell thickness.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    <a href="/en/project/GA17-09998S" target="_blank" >GA17-09998S: Nanopartilces sensitive to reactive oxygen species for biomedical purposes</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Langmuir

  • ISSN

    0743-7463

  • e-ISSN

  • Volume of the periodical

    34

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    2180-2188

  • UT code for WoS article

    000424730500039

  • EID of the result in the Scopus database

    2-s2.0-85041470044