Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00489337" target="_blank" >RIV/61389013:_____/18:00489337 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/18:00076907

Result on the web

<a href="http://dx.doi.org/10.1039/C7TB02888A" target="_blank" >http://dx.doi.org/10.1039/C7TB02888A</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7TB02888A" target="_blank" >10.1039/C7TB02888A</a>

Result language

angličtina

Original language name

Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Original language description

We show that mannan-based conjugates possess exceptional features for multimodal imaging because of their biocompatibility, biodegradability and self-targeting properties. Two new mannan conjugates, containing a gadolinium complex and a fluorescent probe, one based only on polysaccharide and the other one comprising polysaccharide with poly(2-methyl-2-oxazoline) grafts, were prepared and simultaneously visualized in vitro and in vivo by magnetic resonance and fluorescence imaging. The synthesis of these mannan-based complexes was based on alkylation with allyl bromide or grafting with poly(2-methyl-2-oxazoline) chains, followed by a thiol–ene click reaction with cysteamine to introduce primary amino groups into their structure. Finally, the obtained conjugates were functionalized with contrast labels using the corresponding N-hydroxysuccinimide esters. When used to detect lymph nodes, the polymers showed better imaging properties than a commercially available contrast agent.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/NV15-25781A" target="_blank" >NV15-25781A: Novel cancer diagnostics based on glycogen as body´s own nanosized carrier</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

17

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

2584-2596

UT code for WoS article

000431421800011

EID of the result in the Scopus database

2-s2.0-85046642638