Glycogen as an advantageous polymer carrier in cancer theranostics: straightforward in vivo evidence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00525299" target="_blank" >RIV/61389013:_____/20:00525299 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/20:00079801 RIV/00216208:11110/20:10412609 RIV/46747885:24530/20:00007724 RIV/00216208:11120/20:43920262 RIV/00216208:11310/20:10412609
Result on the web
<a href="https://www.nature.com/articles/s41598-020-67277-y" target="_blank" >https://www.nature.com/articles/s41598-020-67277-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-67277-y" target="_blank" >10.1038/s41598-020-67277-y</a>
Alternative languages
Result language
angličtina
Original language name
Glycogen as an advantageous polymer carrier in cancer theranostics: straightforward in vivo evidence
Original language description
As a natural polysaccharide polymer, glycogen possesses suitable properties for use as a nanoparticle carrier in cancer theranostics. Not only it is inherently biocompatible, it can also be easily chemically modified with various moieties. Synthetic glycogen conjugates can passively accumulate in tumours due to enhanced permeability of tumour vessels and limited lymphatic drainage (the EPR effect). For this study, we developed and examined a glycogen-based carrier containing a gadolinium chelate and near-infrared fluorescent dye. Our aim was to monitor biodistribution and accumulation in tumour-bearing rats using magnetic resonance and fluorescence imaging. Our data clearly show that these conjugates possess suitable imaging and tumour-targeting properties, and are safe under both in vitro and in vivo conditions. Additional modification of glycogen polymers with poly(2-alkyl-2-oxazolines) led to a reduction in the elimination rate and lower uptake in internal organs (lower whole-body background: 45% and 27% lower MRI signals of oxazoline-based conjugates in the liver and kidneys, respectively compared to the unmodified version). Our results highlight the potential of multimodal glycogen-based nanopolymers as a carrier for drug delivery systems in tumour diagnosis and treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1-11
UT code for WoS article
000545967200008
EID of the result in the Scopus database
2-s2.0-85086831274