Mannan-based nanodiagnostic agents for targeting sentinel lymph nodes and tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00536794" target="_blank" >RIV/61389013:_____/21:00536794 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10421080 RIV/00023001:_____/21:00080715 RIV/00216208:11310/21:10421080
Result on the web
<a href="https://www.mdpi.com/1420-3049/26/1/146" target="_blank" >https://www.mdpi.com/1420-3049/26/1/146</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules26010146" target="_blank" >10.3390/molecules26010146</a>
Alternative languages
Result language
angličtina
Original language name
Mannan-based nanodiagnostic agents for targeting sentinel lymph nodes and tumors
Original language description
Early detection of metastasis is crucial for successful cancer treatment. Sentinel lymph node (SLN) biopsies are used to detect possible pathways of metastasis spread. We present a unique non-invasive diagnostic alternative to biopsy along with an intraoperative imaging tool for surgery proven on an in vivo animal tumor model. Our approach is based on mannan-based copolymers synergistically targeting: (1) SLNs and macrophage-infiltrated solid tumor areas via the high-affinity DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) receptors and (2) tumors via the enhanced permeability and retention (EPR) effect. The polymer conjugates were modified with the imaging probes for visualization with magnetic resonance (MR) and fluorescence imaging, respectively, and with poly(2-methyl-2-oxazoline) (POX) to lower unwanted accumulation in internal organs and to slow down the biodegradation rate. We demonstrated that these polymer conjugates were successfully accumulated in tumors, SLNs and other lymph nodes. Modification with POX resulted in lower accumulation not only in internal organs, but also in lymph nodes and tumors. Importantly, we have shown that mannan-based polymer carriers are non-toxic and, when applied to an in vivo murine cancer model, and offer promising potential as the versatile imaging agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
26
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
146
UT code for WoS article
000606243900001
EID of the result in the Scopus database
2-s2.0-85099332057