Fluorophilic-lipophilic-hydrophilic poly(2-oxazoline) block copolymers as MRI contrast agents: from synthesis to self-assembly
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00492559" target="_blank" >RIV/61389013:_____/18:00492559 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.macromol.8b00957" target="_blank" >http://dx.doi.org/10.1021/acs.macromol.8b00957</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.8b00957" target="_blank" >10.1021/acs.macromol.8b00957</a>
Alternative languages
Result language
angličtina
Original language name
Fluorophilic-lipophilic-hydrophilic poly(2-oxazoline) block copolymers as MRI contrast agents: from synthesis to self-assembly
Original language description
This work focuses on the synthesis and self-assembly of triphilic poly(2-oxazoline) triblock copolymers with high fluorine content toward our future aim of developing poly(2-oxazoline) magnetic resonance imaging (MRI) contrast agents. A highly fluorinated 2-substituted-2-oxazoline monomer, namely 2-(1H,1H,2H,2H-perfluorooctyl)-2-oxazoline, was synthesized using the Grignard reaction. The polymerization kinetics of the synthesized monomer was studied, and it was used for the preparation of triblock copolymers with hydrophilic 2-methyl-2-oxazoline, hydrophobic 2-octyl-2-oxazoline, and fluorophilic blocks by cationic ring-opening polymerization yielding polymers with low relatively dispersity (1.2-1.4). The presence of the blocks with the different nature in one copolymer structure facilitated self-assembly of the copolymers in water and dimethyl sulfoxide as observed by dynamic light scattering, cryo-transmission electron microscopy, and small-angle neutron scattering. The nanoparticle morphology is strongly influenced by the order and length of each block and the nature of solvent, leading to nanoparticles with core-shell structure as confirmed by small-angle neutron scattering. The reported poly(2-oxazoline) block copolymers with high fluorine content have high potential for future development of MRI contrast agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GA17-00973S" target="_blank" >GA17-00973S: Lipid Cubic Phases for Drug Delivery and Nanocrystallization</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecules
ISSN
0024-9297
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
6047-6056
UT code for WoS article
000442185700061
EID of the result in the Scopus database
2-s2.0-85051520964