Fluorine-containing block and gradient copoly(2-oxazoline)s based on 2-(3,3,3-trifluoropropyl)-2-oxazoline: a quest for the optimal self-assembled structure for 19F imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543732" target="_blank" >RIV/61389013:_____/21:00543732 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10436083 RIV/00216208:11310/21:10436083 RIV/46747885:24220/21:00008865

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.1c00367" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.1c00367</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.biomac.1c00367" target="_blank" >10.1021/acs.biomac.1c00367</a>

Result language

angličtina

Original language name

Fluorine-containing block and gradient copoly(2-oxazoline)s based on 2-(3,3,3-trifluoropropyl)-2-oxazoline: a quest for the optimal self-assembled structure for 19F imaging

Original language description

The use of fluorinated contrast agents in magnetic resonance imaging (MRI) facilitates improved image quality due to the negligible amount of endogenous fluorine atoms in the body. In this work, we present a comprehensive study of the influence of the amphiphilic polymer structure and composition on its applicability as contrast agents in 19F MRI. Three series of novel fluorine-containing poly(2-oxazoline) copolymers and terpolymers, hydrophilic–fluorophilic, hydrophilic–lipophilic–fluorophilic, and hydrophilic–thermoresponsive–fluorophilic, with block and gradient distributions of the fluorinated units, were synthesized. It was discovered that the CF3 in the 2-(3,3,3-trifluoropropyl)-2-oxazoline (CF3EtOx) group activated the cationic chain end, leading to faster copolymerization kinetics, whereby spontaneous monomer gradients were formed with accelerated incorporation of 2-methyl-2-oxazoline or 2-n-propyl-2-oxazoline with a gradual change to the less-nucleophilic CF3EtOx monomer. The obtained amphiphilic copolymers and terpolymers form spherical or wormlike micelles in water, which was confirmed using transmission electron microscopy (TEM), while small-angle X-ray scattering (SAXS) revealed the core–shell or core–double-shell morphologies of these nanoparticles. The core and shell sizes obey the scaling laws for starlike micelles predicted by the scaling theory. Biocompatibility studies confirm that all copolymers obtained are noncytotoxic and, at the same time, exhibit high sensitivity during in vitro 19F MRI studies. The gradient copolymers provide the best 19F MRI signal-to-noise ratio in comparison with the analogue block copolymer structures, making them most promising as 19F MRI contrast agents.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomacromolecules

ISSN

1525-7797

e-ISSN

1526-4602

Volume of the periodical

22

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

2963-2975

UT code for WoS article

000674171500016

EID of the result in the Scopus database

2-s2.0-85110277175