Antioxidant polymer-modified maghemite nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00496525" target="_blank" >RIV/61389013:_____/19:00496525 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304885318317438?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885318317438?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmmm.2018.10.081" target="_blank" >10.1016/j.jmmm.2018.10.081</a>
Alternative languages
Result language
angličtina
Original language name
Antioxidant polymer-modified maghemite nanoparticles
Original language description
Natural antioxidants, such as epigallocatechin-3-gallate and related phenolic compounds from tea, enhance particle cell-interactions and cellular uptake. In this study, surface of superparamagnetic iron oxide nanoparticles prepared by co-precipitation of Fe chlorides was modified with silica, polyethylenimine, poly(ethylene glycol), and poly(l-lysine) to protect the iron oxide core from redox-reactions with phenols, enhance uptake by the cells, prevent the particle aggregation, or enable conjugation with several phenol-based antioxidants. To reveal the relation between the particle uptake and chemical structure of the phenolic antioxidants, five of them were selected, namely phenol, phloroglucinol, chlorogenic, gallic, and tannic acid. After incubation of the phenol-modified nanoparticles with U87MG human glioma cells, intracellular levels of the reactive oxygen species were reduced in a similar manner, as measured by flow cytometry. Colorimetric iron assay revealed a comparable level of cell-associated particles, which was mostly independent on the applied external magnetic field. The results suggest that the poly(l-lysine)-based coating is responsible for the antioxidant effects of the particles. The phenol- and poly(l-lysine)-coatings enable effective colloidal stability in aqueous media and enhance cellular internalization of the nanoparticles.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GC16-01128J" target="_blank" >GC16-01128J: Antioxidative magnetic nanoparticles based on natural antioxidants: Nanoparticle-cell interactions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Magnetism and Magnetic Materials
ISSN
0304-8853
e-ISSN
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Volume of the periodical
473
Issue of the periodical within the volume
1 March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
517-526
UT code for WoS article
000450580900081
EID of the result in the Scopus database
2-s2.0-85056468814