In situ in vivo radiolabeling of polymer-coated hydroxyapatite nanoparticles to track their biodistribution in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00503770" target="_blank" >RIV/61389013:_____/19:00503770 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/19:00331025 RIV/61989592:15110/19:73595059

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0927776519302061?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927776519302061?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfb.2019.03.057" target="_blank" >10.1016/j.colsurfb.2019.03.057</a>

Result language

angličtina

Original language name

In situ in vivo radiolabeling of polymer-coated hydroxyapatite nanoparticles to track their biodistribution in mice

Original language description

The imaging of healthy tissues and solid tumors benefits from the application of nanoparticle probes with altered pharmacokinetics, not available to low molecular weight compounds. However, the distribution and accumulation of nanoprobes in vivo typically take at least tens of hours to be efficient. For nanoprobes bearing a radioactive label, this is contradictory to the requirement of minimizing the radiation dose for patients by using as-short-as-feasible half-life radionuclides in diagnostics. Thus, we developed a two-stage diagnostic concept for monitoring long-lasting targeting effects with short-lived radioactive labels using bone-mimicking biocompatible polymer-coated and colloidally fully stabilized hydroxyapatite nanoparticles (HAP NPs) and bone-seeking radiopharmaceuticals. Within the pretargeting stage, the nonlabeled nanoparticles are allowed to circulate in the blood. Afterward, 99mTc-1-hydroxyethylidene-1.1-diphosphonate (99mTc-HEDP) is administered intravenously for in situ labeling of the nanoparticles and subsequent single-photon emission computed tomography/computed tomography (SPECT/CT) visualization. The HAP NPs, stabilized with tailored hydrophilic polymers, are not cytotoxic in vitro, as shown by several cell lines. The polymer coating prolongs the circulation of HAP NPs in the blood. The nanoparticles were successfully labeled in vivo with 99mTc-HEDP, 1 and 24 h after injection, and they were visualized by SPECT/CT over time in healthy mice.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/NV16-30544A" target="_blank" >NV16-30544A: New multistage nanodiagnostics for cancer imaging and prediction of antiangiogenic therapy efficacy</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Colloids and Surfaces B-Biointerfaces

ISSN

0927-7765

e-ISSN

—

Volume of the periodical

179

Issue of the periodical within the volume

1 July

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

143-152

UT code for WoS article

000471736600017

EID of the result in the Scopus database

2-s2.0-85063737246