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Tubes for detection of cholinesterase inhibitors - unique effects of Neusilin on the stability of butyrylcholinesterase-impregnated carriers

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00504873" target="_blank" >RIV/61389013:_____/19:00504873 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21460/19:00340441 RIV/62157124:16370/19:43877743

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0141022919300699?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141022919300699?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.enzmictec.2019.05.002" target="_blank" >10.1016/j.enzmictec.2019.05.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tubes for detection of cholinesterase inhibitors - unique effects of Neusilin on the stability of butyrylcholinesterase-impregnated carriers

  • Original language description

    Detection tubes are small devices for the colorimetric enzymatic detection of cholinesterase inhibitors such as sarin, soman, VX nerve agents and substances denoted as Novichok. These detectors contain carriers in the form of pellets with immobilized cholinesterase, substrate and detection reagent. Their advantages are portability, sensitivity and simplicity, enabling fast detection of such compounds from air and water in case of a terrorist attack or war. In general, maintaining the stability of an enzyme for a longer time is very problematic. Therefore, its further enhancement is required for safety and financial reasons. In this study, the stability of our patented carriers in the form of pellets with immobilized butyrylcholinesterase containing an increasing amount of the unique sorbent Neusilin® US2 was evaluated. The samples containing Neusilin maintained the stability of the immobilized enzyme for a longer time even at higher temperature and humidity than the currently commercially used carrier without Neusilin, allowing improved detection of nerve agents.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Enzyme and Microbial Technology

  • ISSN

    0141-0229

  • e-ISSN

  • Volume of the periodical

    128

  • Issue of the periodical within the volume

    September

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    26-33

  • UT code for WoS article

    000472988700004

  • EID of the result in the Scopus database

    2-s2.0-85065427273