Interaction pathways and structure-chemical transformations of alginate gels in physiological environments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00510805" target="_blank" >RIV/61389013:_____/19:00510805 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00113449 RIV/62157124:16170/19:43877747 RIV/62157124:16270/19:43877747 RIV/62157124:16370/19:43877747
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.9b01052" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.9b01052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.9b01052" target="_blank" >10.1021/acs.biomac.9b01052</a>
Alternative languages
Result language
angličtina
Original language name
Interaction pathways and structure-chemical transformations of alginate gels in physiological environments
Original language description
The remarkably diverse affinity of alginate (ALG) macromolecules for polyvalent metal ions makes cross-linked alginate gels an outstanding biomaterial. Surprisingly, however, very little is known about their interactions and structural transformations in physiological environments. To bridge this gap, we prepared a set of ALG gels cross-linked by various ions and monitored their structural changes at different media simulating gastric and intestinal fluids and cellular environments. For these studies, we used multinuclear solid-state NMR (ss-NMR) spectroscopy, which revealed a range of competitive ion-exchange and interconversion reactions, the rate of which strongly depended on the nature of the cross-linking metal ions. Depending on the environment, ALG chains adopted different forms, such as acidic (hydro)gels stabilized by strong hydrogen bonds, and/or weakly cross-linked Na/H-gels. Simultaneously, the exchanged polyvalent ions extensively interacted with the environment even forming in some cases insoluble phosphate microdomains directly deposited in the ALG bead matrix. The extent of the transformations and incorporation of secondary phases into the alginate beads followed the size and electronegativity of the cross-linking ions. Overall, the applied combination of various macroscopic and biological tests with multinuclear ss-NMR revealed a complex pathway of alginate beads transformations in physiological environments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
4158-4170
UT code for WoS article
000496343800012
EID of the result in the Scopus database
2-s2.0-85074441891