Thermoplastic starch composites with titanium dioxide and vancomycin antibiotic: preparation, morphology, thermomechanical properties, and antimicrobial susceptibility testing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00521495" target="_blank" >RIV/61389013:_____/20:00521495 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10410828 RIV/00216208:11130/20:10410828 RIV/00064203:_____/20:10410828

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fmats.2020.00009/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmats.2020.00009/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmats.2020.00009" target="_blank" >10.3389/fmats.2020.00009</a>

Result language

angličtina

Original language name

Thermoplastic starch composites with titanium dioxide and vancomycin antibiotic: preparation, morphology, thermomechanical properties, and antimicrobial susceptibility testing

Original language description

Biodegradable composites of thermoplastic starch (TPS), titanium dioxide particles (TiO2, average size 0.2 μm), and/or antibiotic (ATB, vancomycin) were prepared. Light and electron microscopy demonstrated that our recently developed, two-step preparation procedure yielded highly homogeneous TPS matrix with well-dispersed TiO2 particles even for high filler concentrations (up to 20%). Oscillatory shear rheometry showed an increase in viscosity of TPS after addition of TiO2 and ATB (from ca 2 × 105 Pa·s to ca 1 × 106 Pa·s at 1 rad/s and 120°C). However, the high viscosity of TPS/TiO2/ATB composites did not prevent reproducible preparation of the composites by melt-mixing. Dynamic mechanical analysis proved a significant increase in shear moduli (storage, loss and complex modulus) of TPS after addition of TiO2 and ATB (storage modulus increased from ca 25 MPa to more than 600 MPa at 1.33 rad/s at room temperature). Both rheological and mechanical properties indicated strong interactions among TPS matrix, filler, and antibiotics. The final TPS composites were soft enough to be cut with a sharp blade at room temperature, the TPS matrix was fully biodegradable, the TiO2 filler was biocompatible, and the ATB could be released locally during the matrix degradation. Selected samples were tested for bacterial susceptibility using standard tube dilution test and disk diffusion test. The results proved that the ATB retained its bacteriostatic properties after the thermal processing of the composites. Therefore, the prepared TPS/TiO2/ATB composites represent a promising material for biomedical applications related to the local release of antibiotics.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Materials

ISSN

2296-8016

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

January

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1-13

UT code for WoS article

000514905800001

EID of the result in the Scopus database

2-s2.0-85079497643