Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00524042" target="_blank" >RIV/61389013:_____/20:00524042 - isvavai.cz</a>
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/nnm-2019-0407" target="_blank" >https://www.futuremedicine.com/doi/10.2217/nnm-2019-0407</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/nnm-2019-0407" target="_blank" >10.2217/nnm-2019-0407</a>
Alternative languages
Result language
angličtina
Original language name
Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions
Original language description
We aimed to develop nanoemulsions containing phosphodiesterase 4 inhibitor rolipram with different droplet sizes, to evaluate the anti-inflammatory effect against activated neutrophils and a related lung injury. We prepared nanoemulsions of three different sizes, 68, 133 and 188 nm. The nanoemulsion inhibited the superoxide anion but not elastase release in primary human neutrophils. The large-sized nanoemulsions were mostly internalized by neutrophils, resulting in the reduction of intracellular Ca2+ half-life. The peripheral organ distribution of near-infrared dye-tagged nanoemulsions increased, following the decrease in droplet diameter. Rolipram entrapment into intravenous nanoemulsions ameliorated pulmonary inflammation. The smallest droplet size showed improvement, compared with the largest size. We established a foundation for the development of nanoemulsions against inflamed lung disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomedicine
ISSN
1743-5889
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
19
Pages from-to
773-791
UT code for WoS article
000526854700004
EID of the result in the Scopus database
2-s2.0-85083002848