Cerium oxide-decorated .gamma.-Fe2O3 nanoparticles: design, synthesis and in vivo effects on parameters of oxidative stress

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00532094" target="_blank" >RIV/61389013:_____/20:00532094 - isvavai.cz</a>

Alternative codes found

RIV/67985530:_____/20:00532094 RIV/00023001:_____/20:00080078

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fchem.2020.00682/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fchem.2020.00682/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fchem.2020.00682" target="_blank" >10.3389/fchem.2020.00682</a>

Result language

angličtina

Original language name

Cerium oxide-decorated .gamma.-Fe2O3 nanoparticles: design, synthesis and in vivo effects on parameters of oxidative stress

Original language description

Magnetic γ-Fe2O3/CeOx nanoparticles were obtained by basic coprecipitation/oxidation of iron chlorides with hydrogen peroxide, followed by precipitation of Ce(NO3)3 with ammonia. The appearance of CeOx on the magnetic particle surface was confirmed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), and elemental analysis. A magnetometer was used to measure the magnetic properties of γ-Fe2O3/CeOx. The relatively high saturation magnetization of the particles (41.1 A·m2/kg) enabled magnetic separation. The surface of γ-Fe2O3/CeOx particles was functionalized with PEG-neridronate of two different molecular weights to ensure colloidal stability and biocompatibility. The ability of the particles to affect oxidative stress in hereditary hypertriglyceridemic (HHTg) rats was tested by biological assay of the liver, kidney cortex, and brain tissues. An improvement was observed in both enzymatic [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] and non-enzymatic (reduced (GSH) and oxidized (GSSG) glutathione) levels of antioxidant defense and lipid peroxidation parameters [4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)]. The results corresponded with chemical determination of antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, proving that in the animal model γ-Fe2O3/CeOx@PEG2,000 nanoparticles effectively scavenged radicals due to the presence of cerium oxide, in turn decreasing oxidative stress. These particles may therefore have the potential to reduce disorders associated with oxidative stress and inflammation.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Chemistry

ISSN

2296-2646

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

August

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1-13

UT code for WoS article

000564335300001

EID of the result in the Scopus database

2-s2.0-85103085623