Designed boron‐rich polymeric nanoparticles based on nano‐ion pairing for boron delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F20%3A00534511" target="_blank" >RIV/61389013:_____/20:00534511 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10419873
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202001699" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202001699</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.202001699" target="_blank" >10.1002/chem.202001699</a>
Alternative languages
Result language
angličtina
Original language name
Designed boron‐rich polymeric nanoparticles based on nano‐ion pairing for boron delivery
Original language description
Boron‐rich particles with the boron fraction ca.10–20 wt % of controllable shape and size that can be easily prepared via simple ion co‐assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core‐shell polymeric nanoparticles were prepared by co‐assembly of cationic PEO‐block‐PGEA diblock copolymer with sodium closo‐dodecaborate, Na2[B12H12]. This is the first example of polymer nanoparticles based on [B12H12]2−nano‐ion pairing. The high [B12H12]2− loading is proven by calorimetry at physiological salt concentration. As a result of rational design, rod‐, worm‐ and sphere‐like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod‐like particles yielded the highest internalization capability in all tested cell lines.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA19-13458S" target="_blank" >GA19-13458S: Nanomaterials based on co-assembly of triblock copolymers with macroions and other atypical ions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
63
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
14283-14289
UT code for WoS article
000574858000001
EID of the result in the Scopus database
2-s2.0-85092046204