Microwave-assisted RAFT polymerization of N-(2-hydroxypropyl) methacrylamide and its relevant copolymers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00541436" target="_blank" >RIV/61389013:_____/21:00541436 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1381514821000675?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1381514821000675?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.reactfunctpolym.2021.104875" target="_blank" >10.1016/j.reactfunctpolym.2021.104875</a>
Alternative languages
Result language
angličtina
Original language name
Microwave-assisted RAFT polymerization of N-(2-hydroxypropyl) methacrylamide and its relevant copolymers
Original language description
A rapid and eco-friendly reversible addition-fragmentation chain transfer (RAFT) polymerization reaction of the N-(2-hydroxypropyl) methacrylamide (HPMA) monomer under microwave irradiation (MWI) was demonstrated. A systematic investigation to determine the optimal conditions for the polymerization, such as the reaction time, solvents, monomer stoichiometry and RAFT agents, was implemented. The polymerization kinetics were obtained using two different chain transfer agents (CTAs), namely, commercial 4-cyano-4-(phenylcarbonothioylthio)pentanoic acid and synthesized 4-cyano-4-(((ethylthio)carbonothioyl)thio)pentanoic acid, in the presence of 4,4′-azobis(4-cyanovaleric acid) as the initiator in various solvents. The controlled living character of the RAFT polymerization under MWI conditions was demonstrated by the linear increase in the number-average molecular weight (Mn) with monomer conversion. Moreover, good agreement between the theoretical and experimental Mn values was verified with pseudo-first-order kinetic plots, with low dispersities (Đ ≤ 1.04) if a favorable solvent and/or CTA was chosen. In addition, the ability of MWI to facilitate copolymer formation was demonstrated by the preparation of relevant copolymers, such as poly(HPMA-b-bocAPMA), poly(HPMA-b-MABH) and poly(HPMA-b-PDPA). Altogether, these facile synthetic approaches can find applications for the synthesis of PHPMA-based homo- and copolymers that have already been clinically tested and serve as hydrophilic high-potential alternatives to polyethylene oxide.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Reactive and Functional Polymers
ISSN
1381-5148
e-ISSN
1873-166X
Volume of the periodical
162
Issue of the periodical within the volume
May
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
104875
UT code for WoS article
000640441600001
EID of the result in the Scopus database
2-s2.0-85102843293