Formation of phosphonate coatings for improved chemical stability of upconverting nanoparticles under physiological conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00542467" target="_blank" >RIV/61389013:_____/21:00542467 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2021/DT/D1DT00304F#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/DT/D1DT00304F#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D1DT00304F" target="_blank" >10.1039/D1DT00304F</a>
Alternative languages
Result language
angličtina
Original language name
Formation of phosphonate coatings for improved chemical stability of upconverting nanoparticles under physiological conditions
Original language description
Upconverting nanoparticles (UCNPs) are being extensively investigated for applications in bioimaging because of their ability to emit ultraviolet, visible, and near-infrared light. NaYF4 is one of the most suitable host matrices for producing high-intensity upconversion fluorescence. UCNPs based on NaYF4 are not chemically stable in aqueous media. To prevent dissolution, their surfaces should be modified. We studied the formation of protective phosphonate coatings made of ethylenediamine(tetramethylenephosphonic acid), alendronic acid, and poly(ethylene glycol)-neridronate on cubic NaYF4 nanoparticles and hexagonal Yb3+,Er3+-doped upconverting NaYF4 nanoparticles (β-UCNPs). The effects of synthesis temperature and ultrasonic agitation on the quality of the coatings were studied. The formation of the coatings was investigated by transmission electron microscopy, zeta-potential measurements, and infrared spectroscopy. The quality of the phosphonate coatings was examined with respect to preventing the dissolution of the NPs in phosphate-buffered saline (PBS). The dissolution tests were carried out under physiological conditions (37 °C and pH 7.4) for 3 days and were followed by measurements of the dissolved fluoride with an ion-selective electrode. We found that the protection of the phosphonate coatings can be significantly increased by synthesizing them at 80 °C. At the same time, the coatings obtained at this temperature suppressed the surface quenching of the upconversion fluorescence in β-UCNPs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA21-04420S" target="_blank" >GA21-04420S: Protective coatings against dissolution/disintegration of upconverting lanthanide-based nanoparticles in biological media</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dalton Transactions
ISSN
1477-9226
e-ISSN
1477-9234
Volume of the periodical
50
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
6588-6597
UT code for WoS article
000643904000001
EID of the result in the Scopus database
2-s2.0-85106156468