2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543672" target="_blank" >RIV/61389013:_____/21:00543672 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10427616 RIV/00216208:11130/21:10427616
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.202100086" target="_blank" >10.1002/macp.202100086</a>
Alternative languages
Result language
angličtina
Original language name
2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy
Original language description
Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels are well known in ophthalmological applications and recently investigated as drug delivery systems. The study represents a theoretical approach where the sorption/desorption experiments and spectroscopic study is used to describe the influence of the pHEMA network structure on the sorption capacity and mechanism of the release of topotecan (TPT) and vincristine (VCR). The hydrogels are synthesized by free-radical crosslinking polymerization of HEMA monomer with ethylene glycol dimethacrylate as a crosslinker in the concentration range from 0.3 to 1 wt%. Experimental data from sorption kinetics are evaluated using sorption kinetic models and sorption isotherms, drug release mechanism is assessed by two different models and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is employed to describe the polymer-drug interaction. pHEMA hydrogels exhibit higher affinity for TPT than for VCR and hydrogels prepared with 0.5 wt% of crosslinker show the maximum sorption capacity for both drugs. Physisorption is proved to be the sorption mechanism. Analyzing the FTIR spectra, it is concluded that the hydrophobic crosslinks play an important role in the interaction of the hydrogel backbone with molecules of both drugs.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
1521-3935
Volume of the periodical
222
Issue of the periodical within the volume
13
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
2100086
UT code for WoS article
000646753700001
EID of the result in the Scopus database
2-s2.0-85105077530