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2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00543672" target="_blank" >RIV/61389013:_____/21:00543672 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/21:10427616 RIV/00216208:11130/21:10427616

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/macp.202100086</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/macp.202100086" target="_blank" >10.1002/macp.202100086</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy

  • Original language description

    Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels are well known in ophthalmological applications and recently investigated as drug delivery systems. The study represents a theoretical approach where the sorption/desorption experiments and spectroscopic study is used to describe the influence of the pHEMA network structure on the sorption capacity and mechanism of the release of topotecan (TPT) and vincristine (VCR). The hydrogels are synthesized by free-radical crosslinking polymerization of HEMA monomer with ethylene glycol dimethacrylate as a crosslinker in the concentration range from 0.3 to 1 wt%. Experimental data from sorption kinetics are evaluated using sorption kinetic models and sorption isotherms, drug release mechanism is assessed by two different models and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is employed to describe the polymer-drug interaction. pHEMA hydrogels exhibit higher affinity for TPT than for VCR and hydrogels prepared with 0.5 wt% of crosslinker show the maximum sorption capacity for both drugs. Physisorption is proved to be the sorption mechanism. Analyzing the FTIR spectra, it is concluded that the hydrophobic crosslinks play an important role in the interaction of the hydrogel backbone with molecules of both drugs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Macromolecular Chemistry and Physics

  • ISSN

    1022-1352

  • e-ISSN

    1521-3935

  • Volume of the periodical

    222

  • Issue of the periodical within the volume

    13

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    11

  • Pages from-to

    2100086

  • UT code for WoS article

    000646753700001

  • EID of the result in the Scopus database

    2-s2.0-85105077530