Direct comparison of analogous amphiphilic gradient and block polyoxazolines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00545562" target="_blank" >RIV/61389013:_____/21:00545562 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/21:00545562 RIV/00216208:11110/21:10433668 RIV/00216208:11140/21:10433668 RIV/00216208:11310/21:10433668
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.0c02674" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.0c02674</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.0c02674" target="_blank" >10.1021/acs.macromol.0c02674</a>

Result language
angličtina
Original language name
Direct comparison of analogous amphiphilic gradient and block polyoxazolines
Original language description
Both gradient and block copolymers can be used as drug delivery systems, but their relative (dis)advantages remain unknown. Thus, we directly compared analogous amphiphilic gradient and block polyoxazolines for their physicochemical properties and potential as building components of nanodrugs. For this purpose, we prepared a library of 18 polymers with varying ratios of monomeric units, using 2-methyl-2-oxazoline (MeOx) as a hydrophilic monomer and 2-phenyl-2-oxazoline (PhOx), 2-(4-butylphenyl)-2-oxazoline (BuPhOx), or 2-(4-butoxyphenyl)-2-oxazoline (BuOPhOx) as a hydrophobic monomer, and determined their homo/heteropolymerization kinetics. Our results showed that gradient copolymers had broader glass transition intervals and formed nanoparticles several times smaller and more compact than the corresponding block analogs. In particular, PMeOx70-grad-PhOx30 and PMeOx70-grad-BuPhOx30 exhibited a significantly higher drug loading capacity and entrapment efficiency than their corresponding block analogs. Notwithstanding these differences, all polymers were cyto- and hemocompatible in vitro. Therefore, analogous gradient and block copolymers may be alternatively used for specific biomedical applications.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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