Nanocrystalline chloroxine possesses broad-spectrum antimicrobial activities and excellent skin tolerability in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00553047" target="_blank" >RIV/61389013:_____/22:00553047 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/22:10436492 RIV/00216208:11130/22:10436492 RIV/62157124:16170/22:43879894
Result on the web
<a href="https://www.futuremedicine.com/doi/epub/10.2217/nnm-2021-0323" target="_blank" >https://www.futuremedicine.com/doi/epub/10.2217/nnm-2021-0323</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/nnm-2021-0323" target="_blank" >10.2217/nnm-2021-0323</a>
Alternative languages
Result language
angličtina
Original language name
Nanocrystalline chloroxine possesses broad-spectrum antimicrobial activities and excellent skin tolerability in mice
Original language description
Background: Antimicrobial submicrometer particles are being studied as promising interventions against a wide range of skin conditions, such as fungal or bacterial infections. Aims: To submicronize chloroxine, the crystalline compound 5,7-dichloro-8-hydroxyquinoline, by nanoprecipitation and characterize the resulting assemblies. Methods: The chloroxine particles were stabilized by a nonionic surfactant and were studied by a broth microdilution assay against 20 medically important bacteria and fungi. The intervention was studied using a murine model of skin irritation. Results & conclusion: Chloroxine nanoparticles with a diameter of 600–800 nm exhibit good tolerability in terms of skin irritation in vivo and good antimicrobial activity. Thus, the fabricated formulation shows great promise for interventions for both cutaneous infection control and prophylaxis.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/GA21-01090S" target="_blank" >GA21-01090S: Actively self-cleaning antibiofilm polymer surfaces</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomedicine
ISSN
1743-5889
e-ISSN
1748-6963
Volume of the periodical
17
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
137-149
UT code for WoS article
000741019700001
EID of the result in the Scopus database
2-s2.0-85123968595