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Kill&repel coatings: the marriage of antifouling and bactericidal properties to mitigate and treat wound infections

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00554521" target="_blank" >RIV/61389013:_____/22:00554521 - isvavai.cz</a>

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202106656" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202106656</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/adfm.202106656" target="_blank" >10.1002/adfm.202106656</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Kill&repel coatings: the marriage of antifouling and bactericidal properties to mitigate and treat wound infections

  • Original language description

    Wound infections originate when exogenous or endogenous bacterial pathogens can circumvent the barrier of the wound dressing and invade the wound bed. Bacterial colonization causes inflammation, stalls the healing process, and carries the risk of dissemination to other tissues. In addition, current antimicrobial dressings fail to resolve an infection once it has been established because debris of the killed bacteria rapidly accumulates on their surface and hampers the antimicrobial action. Faced with this challenge, hybrid synthetic-natural water-soluble macromolecules are designed that self-assemble onto the surface of dressings to generate an antifouling brush functionalized with endolysin, a bactericidal enzyme that poses no harm for eukaryotic cells. The simultaneous action of the brush and the enzyme not only prevents the colonization of the dressing, but also enables the coating to kill planktonic bacteria with even higher efficiency than the free enzyme. Remarkably, the Kill&Repel coating could completely eradicate bacteria in a simulated infection without allowing the adhesion of residues on the surface. Thus, this strategy opens a revolutionary approach for protecting and treating an infected wound in a safer and more efficient manner.n

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advanced Functional Materials

  • ISSN

    1616-301X

  • e-ISSN

    1616-3028

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    13

  • Pages from-to

    2106656

  • UT code for WoS article

    000709160800001

  • EID of the result in the Scopus database

    2-s2.0-85117376027