Tumor stimulus-responsive biodegradable diblock copolymer conjugates as efficient anti-cancer nanomedicines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00556939" target="_blank" >RIV/61389013:_____/22:00556939 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2075-4426/12/5/698" target="_blank" >https://www.mdpi.com/2075-4426/12/5/698</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jpm12050698" target="_blank" >10.3390/jpm12050698</a>
Alternative languages
Result language
angličtina
Original language name
Tumor stimulus-responsive biodegradable diblock copolymer conjugates as efficient anti-cancer nanomedicines
Original language description
Biodegradable nanomedicines are widely studied as candidates for the effective treatment of various cancerous diseases. Here, we present the design, synthesis and evaluation of biodegradable polymer-based nanomedicines tailored for tumor-associated stimuli-sensitive drug release and polymer system degradation. Diblock polymer systems were developed, which enabled the release of the carrier drug, pirarubicin, via a pH-sensitive spacer allowing for the restoration of the drug cytotoxicity solely in the tumor tissue. Moreover, the tailored design enables the matrix-metalloproteinases- or reduction-driven degradation of the polymer system into the polymer chains excretable from the body by glomerular filtration. Diblock nanomedicines take advantage of an enhanced EPR effect during the initial phase of nanomedicine pharmacokinetics and should be easily removed from the body after tumor microenvironment-associated biodegradation after fulfilling their role as a drug carrier. In parallel with the similar release profiles of diblock nanomedicine to linear polymer conjugates, these diblock polymer conjugates showed a comparable in vitro cytotoxicity, intracellular uptake, and intratumor penetration properties. More importantly, the diblock nanomedicines showed a remarkable in vivo anti-tumor efficacy, which was far more superior than conventional linear polymer conjugates. These findings suggested the advanced potential of diblock polymer conjugates for anticancer polymer therapeutics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LTAUSA18083" target="_blank" >LTAUSA18083: Advanced polymer nanotheranostics based on biodegradable biocompatible carriers</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Personalized Medicine
ISSN
2075-4426
e-ISSN
2075-4426
Volume of the periodical
12
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
698
UT code for WoS article
000801380300001
EID of the result in the Scopus database
2-s2.0-85129837930