Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00559150" target="_blank" >RIV/61389013:_____/22:00559150 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/22:00559150 RIV/49777513:23640/22:43965967
Result on the web
<a href="https://link.springer.com/article/10.1007/s10570-022-04686-4" target="_blank" >https://link.springer.com/article/10.1007/s10570-022-04686-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10570-022-04686-4" target="_blank" >10.1007/s10570-022-04686-4</a>
Alternative languages
Result language
angličtina
Original language name
Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength
Original language description
Fabricating mechanically strong hydrogels that can withstand the conditions in internal tissues is a challenging task. We have designed hydrogels based on multicomponent systems by combining chitosan, starch/cellulose, PVA, and PEDOT:PSS via one-pot synthesis. The starch-based hydrogels were homogeneous, while the cellulose-based hydrogels showed the presence of cellulose micro- and nanofibers. The cellulose-based hydrogels demonstrated a swelling ratio between 121 and 156%, while the starch-based hydrogels showed higher values, from 234 to 280%. Tensile tests indicated that the presence of starch in the hydrogels provided high flexibility (strain at break > 300%), while combination with cellulose led to the formation of stiffer hydrogels (elastic moduli 3.9–6.6 MPa). The ultimate tensile strength for both types of hydrogels was similar (2.8–3.9 MPa). The adhesion and growth of human osteoblast-like SAOS-2 cells was higher on hydrogels with cellulose than on hydrogels with starch, and was higher on hydrogels with PEDOT:PSS than on hydrogels without this polymer. The metabolic activity of cells cultivated for 3 days in the hydrogel infusions indicated that no acutely toxic compounds were released. This is promising for further possible applications of these hydrogels in tissue engineering or in wound dressings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA20-01641S" target="_blank" >GA20-01641S: Degradable nanocellulose as a novel temporary scaffold for tissue engineering</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellulose
ISSN
0969-0239
e-ISSN
1572-882X
Volume of the periodical
29
Issue of the periodical within the volume
12
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
21
Pages from-to
6697-6717
UT code for WoS article
000815422900001
EID of the result in the Scopus database
2-s2.0-85132706794