Anionically functionalized glycogen encapsulates melittin by multivalent interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00559765" target="_blank" >RIV/61389013:_____/22:00559765 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10452322
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.2c00400" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.2c00400</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.2c00400" target="_blank" >10.1021/acs.biomac.2c00400</a>
Alternative languages
Result language
angličtina
Original language name
Anionically functionalized glycogen encapsulates melittin by multivalent interaction
Original language description
We developed acid-functionalized glycogen conjugates as supramolecular carriers for efficient encapsulation and inhibition of a model cationic peptide melittin─the main component of honeybee venom. For this purpose, we synthesized and characterized a set of glycogens, functionalized to various degrees by several different acid groups. These conjugates encapsulate melittin up to a certain threshold amount, beyond which they precipitate. Computer simulations showed that sufficiently functionalized conjugates electrostatically attract melittin, resulting in its efficient encapsulation in a broad pH range around the physiological pH. Hemolytic assays confirmed in vitro that the effective inhibition of melittin’s hemolytic activity occurs for highly functionalized samples, whereas no inhibition is observed when using low-functionalized conjugates. It can be concluded that functional glycogens are promising carriers for cationic molecular cargos or antidotes against animal venoms under conditions, in which suitable properties such as biodegradability and biocompatibility are crucial.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
1526-4602
Volume of the periodical
23
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
3371-3382
UT code for WoS article
000823599900001
EID of the result in the Scopus database
2-s2.0-85134802029