Rose Bengal-modified upconverting nanoparticles: synthesis, characterization, and biological evaluation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00560844" target="_blank" >RIV/61389013:_____/22:00560844 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10448653
Result on the web
<a href="https://www.mdpi.com/2075-1729/12/9/1383" target="_blank" >https://www.mdpi.com/2075-1729/12/9/1383</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/life12091383" target="_blank" >10.3390/life12091383</a>
Alternative languages
Result language
angličtina
Original language name
Rose Bengal-modified upconverting nanoparticles: synthesis, characterization, and biological evaluation
Original language description
High-quality upconverting NaYF4:Yb3+,Er3+ nanoparticles (UCNPs, 26 nm in diameter) based on lanthanides were synthesized by a high-temperature coprecipitation method. The particles were modified by bisphosphonate-terminated poly(ethylene glycol) (PEG) and Rose Bengal (RB) photosensitizer. The particles were thoroughly characterized using transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, FTIR, and X-ray photoelectron and upconversion luminescence spectroscopy in terms of morphology, hydrodynamic size, composition, and energy transfer to the photosensitizer. Moreover, the singlet oxygen generation from RB-containing UCNPs was investigated using 9,10-diphenylanthracene probe under 980 nm excitation. The cytotoxicity of UCNPs before and after conjugation with RB was evaluated on highly sensitive rat mesenchymal stem cells (rMSCs) and significant differences were found. Correspondingly, consi-derable variations in viability were revealed between the irradiated and non-irradiated rat glioma cell line (C6) exposed to RB-conjugated UCNPs. While the viability of rMSCs was not affected by the presence of UCNPs themselves, the cancer C6 cells were killed after the irradiation at 980 nm due to the reactive oxygen species (ROS) production, thus suggesting the potential of RB-conjugated PEG-modified UCNPs for applications in photodynamic therapy of cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Life
ISSN
2075-1729
e-ISSN
2075-1729
Volume of the periodical
12
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
1383
UT code for WoS article
000859904700001
EID of the result in the Scopus database
2-s2.0-85138731913