Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00573948" target="_blank" >RIV/61389013:_____/23:00573948 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/23:00573948 RIV/00216208:11110/23:10465694 RIV/00216208:11130/23:10465694

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fchem.2023.1207984/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fchem.2023.1207984/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fchem.2023.1207984" target="_blank" >10.3389/fchem.2023.1207984</a>

Result language

angličtina

Original language name

Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

Original language description

Large (120 nm) hexagonal NaYF4:Yb, Er nanoparticles (UCNPs) were synthesized by high-temperature coprecipitation method and coated with poly(ethylene glycol)-alendronate (PEG-Ale), poly (N,N-dimethylacrylamide-co-2-aminoethylacrylamide)-alendronate (PDMA-Ale) or poly(methyl vinyl ether-co-maleic acid) (PMVEMA). The colloidal stability of polymer-coated UCNPs in water, PBS and DMEM medium was investigated by dynamic light scattering, UCNP@PMVEMA particles showed the best stability in PBS. Dissolution of the particles in water, PBS, DMEM and artificial lysosomal fluid (ALF) determined by potentiometric measurements showed that all particles were relatively chemically stable in DMEM. The UCNP@Ale-PEG and UCNP@Ale-PDMA particles were the least soluble in water and ALF, while the UCNP@PMVEMA particles were the most chemically stable in PBS. Green fluorescence of FITC-Ale-modified UCNPs was observed inside the cells, demonstrating successful internalization of particles into cells. The highest uptake was observed for neat UCNPs, followed by UCNP@Ale-PDMA and UCNP@PMVEMA. Viability of C6 cells and rat mesenchymal stem cells (rMSCs) growing in the presence of UCNPs was monitored by Alamar Blue assay. Culturing with UCNPs for 24 h did not affect cell viability. Prolonged incubation with particles for 72 h reduced cell viability to 40%–85% depending on the type of coating and nanoparticle concentration. The greatest decrease in cell viability was observed in cells cultured with neat UCNPs and UCNP@PMVEMA particles. Thanks to high upconversion luminescence, high cellular uptake and low toxicity, PDMA-coated hexagonal UCNPs may find future applications in cancer therapy.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Chemistry

ISSN

2296-2646

e-ISSN

2296-2646

Volume of the periodical

11

Issue of the periodical within the volume

23 June

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1207984

UT code for WoS article

001025012900001

EID of the result in the Scopus database

2-s2.0-85164570429