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Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00562259" target="_blank" >RIV/61389013:_____/22:00562259 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/22:00562259

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0304885322008526?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885322008526?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jmmm.2022.169967" target="_blank" >10.1016/j.jmmm.2022.169967</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering

  • Original language description

    Magnetic polymer nanocomposites manipulatable by an external magnetic field have a great potential for bone tissue regeneration. Various strategies have been proposed for their fabrication, as uniform distribution of magnetic nanoparticles (MNPs) within the polymer matrix remains to be the main challenge. The aim of this study was to design poly(ε-caprolactone) (PCL) matrix containing iron oxide nanoparticles stabilized by saturated fatty acids with the increasing number of carbon atoms, i.e., caprylic (CA), palmitic (PA), and stearic acids (SA). We investigated the effect of the type of fatty acid and the content of particles in nanocomposite membranes on their physicochemical properties and biological response toward the SAOS-2 cells. The incorporation of the MNPs in PCL matrix resulted in a gradual increase of Young’s modulus, a slight decrease of tensile strength, and a significant decrease of stress and strain at break. The addition of SA-stabilized MNPs (1 wt%) in the PCL matrix increased its strength. The membranes containing CA-stabilized MNPs remained non-toxic towards SAOS-2 cells, while the cytotoxicity of other nanocomposites increased with the enhanced length of carbon chains of fatty acids stabilizing MNPs, as well as with their increasing content in membranes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    <a href="/en/project/GA20-07015S" target="_blank" >GA20-07015S: Magnetic Composite Materials for Non-Invasive Cell Stimulation in Tissue Engineering</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Magnetism and Magnetic Materials

  • ISSN

    0304-8853

  • e-ISSN

    1873-4766

  • Volume of the periodical

    563

  • Issue of the periodical within the volume

    1 December

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    11

  • Pages from-to

    169967

  • UT code for WoS article

    000871107000009

  • EID of the result in the Scopus database

    2-s2.0-85138455635