Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00562259" target="_blank" >RIV/61389013:_____/22:00562259 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/22:00562259
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304885322008526?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885322008526?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmmm.2022.169967" target="_blank" >10.1016/j.jmmm.2022.169967</a>
Alternative languages
Result language
angličtina
Original language name
Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering
Original language description
Magnetic polymer nanocomposites manipulatable by an external magnetic field have a great potential for bone tissue regeneration. Various strategies have been proposed for their fabrication, as uniform distribution of magnetic nanoparticles (MNPs) within the polymer matrix remains to be the main challenge. The aim of this study was to design poly(ε-caprolactone) (PCL) matrix containing iron oxide nanoparticles stabilized by saturated fatty acids with the increasing number of carbon atoms, i.e., caprylic (CA), palmitic (PA), and stearic acids (SA). We investigated the effect of the type of fatty acid and the content of particles in nanocomposite membranes on their physicochemical properties and biological response toward the SAOS-2 cells. The incorporation of the MNPs in PCL matrix resulted in a gradual increase of Young’s modulus, a slight decrease of tensile strength, and a significant decrease of stress and strain at break. The addition of SA-stabilized MNPs (1 wt%) in the PCL matrix increased its strength. The membranes containing CA-stabilized MNPs remained non-toxic towards SAOS-2 cells, while the cytotoxicity of other nanocomposites increased with the enhanced length of carbon chains of fatty acids stabilizing MNPs, as well as with their increasing content in membranes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA20-07015S" target="_blank" >GA20-07015S: Magnetic Composite Materials for Non-Invasive Cell Stimulation in Tissue Engineering</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Magnetism and Magnetic Materials
ISSN
0304-8853
e-ISSN
1873-4766
Volume of the periodical
563
Issue of the periodical within the volume
1 December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
169967
UT code for WoS article
000871107000009
EID of the result in the Scopus database
2-s2.0-85138455635