The transmission and toxicity of polymer-bound doxorubicin-containing exosomes derived from human adenocarcinoma cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00564363" target="_blank" >RIV/61389013:_____/22:00564363 - isvavai.cz</a>
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/nnm-2022-0081" target="_blank" >https://www.futuremedicine.com/doi/10.2217/nnm-2022-0081</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/nnm-2022-0081" target="_blank" >10.2217/nnm-2022-0081</a>
Alternative languages
Result language
angličtina
Original language name
The transmission and toxicity of polymer-bound doxorubicin-containing exosomes derived from human adenocarcinoma cells
Original language description
Exosomes are extracellular vesicles with the ability to encapsulate bioactive molecules, such as therapeutics. This study identified a new exosome mediated route of doxorubicin and poly(N-(2-hydroxypropyl)methacrylamide) (pHPMA)-bound doxorubicin trafficking in the tumor mass. Exosome loading was achieved via incubation of the therapeutics with an adherent human breast adenocarcinoma cell line and its derived spheroids. Exosomes were characterized using HPLC, nanoparticle tracking analysis (NTA) and western blotting. The therapeutics were successfully loaded into exosomes. Spheroids secreted significantly more exosomes than adherent cells and showed decreased viability after treatment with therapeutic-loaded exosomes, which confirmed successful transmission. To the best of our knowledge, this study provides the first evidence of pHPMA-drug conjugate secretion by extracellular vesicles.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LTAUSA18083" target="_blank" >LTAUSA18083: Advanced polymer nanotheranostics based on biodegradable biocompatible carriers</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomedicine
ISSN
1743-5889
e-ISSN
1748-6963
Volume of the periodical
17
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
1307-1322
UT code for WoS article
000869390900001
EID of the result in the Scopus database
2-s2.0-85142403255