Surface effect of iron oxide nanoparticles on the suppression of oxidative burst in cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00569400" target="_blank" >RIV/61389013:_____/23:00569400 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/23:00569400

Result on the web

<a href="https://link.springer.com/article/10.1007/s10876-022-02222-9" target="_blank" >https://link.springer.com/article/10.1007/s10876-022-02222-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10876-022-02222-9" target="_blank" >10.1007/s10876-022-02222-9</a>

Result language

angličtina

Original language name

Surface effect of iron oxide nanoparticles on the suppression of oxidative burst in cells

Original language description

Overproduction of reactive oxygen species (ROS) is an unwanted phenomenon, leading to cellular damages. The aim of this study was to investigate the ability of neat and surface-modified iron oxide nanoparticles (IONs) to eliminate ROS produced by immune cells. The employed coating included heparin (ION@Hep) or heparin and chitosan grafted with phenolic compounds famous for antioxidant properties, i.e., gallic acid (ION@Ch-G) or phloroglucinol (ION@CH-P). A total peroxyl radical-trapping potential assay showed that both types of the phenolic compounds-modified IONs exhibited superior radical scavenging activity over the neat and ION@Hep particles at 100 μg/mL. Up to ~ 75 μg/mL, the particles were non-toxic towards RAW 264.7 macrophages. Capability of the particles to limit ROS production was investigated in vitro on polymorphonuclear (PMN) cells isolated from human whole blood and expressed as an ability to reduce the oxidative burst in the stimulated cells, as well as a potential to increase the viability of bacteria cultivated with the PMN cells. The highest viability of bacteria was observed for the neat and ION@Ch-G, while the ION@Ch-G particles also the most effectively inhibited the oxidative burst. The results indicated that ROS scavenging depend on the presence of polymer and selection of phenols, enriching the IONs.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/GC20-02177J" target="_blank" >GC20-02177J: Antioxidant phenolic compound-modified magnetic nanoparticles for treatment of oxidative stress-related pathologies: Study of nano-biointerfaces</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cluster Science

ISSN

1040-7278

e-ISSN

1572-8862

Volume of the periodical

34

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

323-334

UT code for WoS article

000746347000002

EID of the result in the Scopus database

2-s2.0-85123491079