Self-activated antibacterial MOF-based coating on medically relevant polypropylene
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00570888" target="_blank" >RIV/61389013:_____/23:00570888 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/23:43926149 RIV/60461373:22330/23:43926149 RIV/60461373:22340/23:43926149 RIV/44555601:13440/23:43897692
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0169433223007250?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169433223007250?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apsusc.2023.157048" target="_blank" >10.1016/j.apsusc.2023.157048</a>
Alternative languages
Result language
angličtina
Original language name
Self-activated antibacterial MOF-based coating on medically relevant polypropylene
Original language description
Modern medicine is virtually unimaginable without using various auxiliary materials and devices such as catheters or implants. In this context, there is a potential risk of bacterial colonization and biofilm formation on the surface of these devices, which can lead to serious infections and endanger the health of patients. To prevent bacterial colonization, the preparation and utilization of an intelligent self-activating antibacterial coating on the surface of medically-relevant polypropylene (PP) are proposed in this work. The 3D periodic metal–organic framework structure (copper-1,3,5-benzenetricarboxylate, further referred as CuBTC) was covalently immobilized on the surface of the PP film. The immobilized CuBTC layer can effectively release NO• radicals from its endogenous donor – S-Nitrosoglutathion (GSNO). Local NO• generation ensures the surface antifouling properties and efficiently inhibits the bacterial adhesion to PP. Unlike materials requiring an external stimulus to activate their antibacterial properties, the proposed coating responds to increasing concentration of GSNO in body fluids (increasing of GSNO concentration is commonly associated with bacterial infection and inflammatory response). So that, the proposed coating can be efficiently self-activated on the right place and at the right time. Considering the application area of medical PP, we also estimated the stability of CuBTC antimicrobial response.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA21-06065S" target="_blank" >GA21-06065S: New functionalized plasmon-based sensors as tools for cell monitoring and advanced tissue engineering</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Surface Science
ISSN
0169-4332
e-ISSN
1873-5584
Volume of the periodical
623
Issue of the periodical within the volume
30 June
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
157048
UT code for WoS article
000966033400001
EID of the result in the Scopus database
2-s2.0-85151021398