Stimuli-responsive polymer nanoprobes intended for fluorescence-guided surgery of malignant head-and-neck tumors and metastases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00578001" target="_blank" >RIV/61389013:_____/23:00578001 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10464981 RIV/00064203:_____/23:10464981
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202301183" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adhm.202301183</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adhm.202301183" target="_blank" >10.1002/adhm.202301183</a>
Alternative languages
Result language
angličtina
Original language name
Stimuli-responsive polymer nanoprobes intended for fluorescence-guided surgery of malignant head-and-neck tumors and metastases
Original language description
Nano-sized carriers are widely studied as suitable candidates for the advanced delivery of various bioactive molecules such as drugs and diagnostics. Herein, the development of long-circulating stimuli-responsive polymer nanoprobes tailored for the fluorescently-guided surgery of solid tumors is reported. Nanoprobes are designed as long-circulating nanosystems preferably accumulated in solid tumors due to the Enhanced permeability and retention effect, so they act as a tumor microenvironment-sensitive activatable diagnostic. This study designs polymer probes differing in the structure of the spacer between the polymer carrier and Cy7 by employing pH-sensitive spacers, oligopeptide spacers susceptible to cathepsin B-catalyzed enzymatic hydrolysis, and non-degradable control spacer. Increased accumulation of the nanoprobes in the tumor tissue coupled with stimuli-sensitive release behavior and subsequent activation of the fluorescent signal upon dye release facilitated favorable tumor-to-background ratio, a key feature for fluorescence-guided surgery. The probes show excellent diagnostic potential for the surgical removal of intraperitoneal metastasis and orthotopic head and neck tumors with very high efficacy and accuracy. In addition, the combination of macroscopic resection followed by fluorescence-guided surgery using developed probes enable the identification and resection of most of the CAL33 intraperitoneal metastases with total tumor burden reduced to 97.2%.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Healthcare Materials
ISSN
2192-2640
e-ISSN
2192-2659
Volume of the periodical
12
Issue of the periodical within the volume
28
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
2301183
UT code for WoS article
001009793400001
EID of the result in the Scopus database
2-s2.0-85161969501