One-pot/simultaneous synthesis of PHPMA-g-PLA copolymers via metal-free ROP/RAFT polymerization and their self-assembly from micelles to thermoresponsive vesicles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00579131" target="_blank" >RIV/61389013:_____/23:00579131 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/macp.202300271" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/macp.202300271</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.202300271" target="_blank" >10.1002/macp.202300271</a>
Alternative languages
Result language
angličtina
Original language name
One-pot/simultaneous synthesis of PHPMA-g-PLA copolymers via metal-free ROP/RAFT polymerization and their self-assembly from micelles to thermoresponsive vesicles
Original language description
The present article reports a simple and straightforward approach to access thermoresponsive graft copolymers based on lactide (LA) and a methacrylic monomer, 2-hydroxypropyl methacrylate (HPMA), using a synthesized carboxy-functionalized trithiocarbonate-based chain transfer agent. One protocol involves a metal-free simultaneous synthesis through a combination of reversible addition-fragmentation chain transfer polymerization and organic acid-catalyzed ring-opening polymerization, which follows first-order kinetics. The resulting copolymers with a controlled structure exhibit remarkably narrow molecular weight distributions (Ð < 1.10). Within this framework, the self-assembly of PHPMA-g-PLA graft copolymers (GCs) into nanoparticles (NPs) is demonstrated at concentrations of 0.2 and 0.5 wt.%, respectively. The displacement method, based on the rapid injection of the organic solvent (acetone) into an aqueous medium under vigorous stirring, produces spherical NPs such as micelles, vesicles, or non-spherical “lumpy rods”. The presence of a pseudo-thermoresponsive segment (PHPMA) in GCs facilitates stimulus-responsive self-assembly behavior. Well-defined spherical NPs—primarily vesicles of substantial size—develop upon heating above the glass transition temperature (Tg ≈35–36 °C) of the GCs in an acetone–water (80/20 wt.%) mixture. Last, specific interactions between the obtained PHPMA-g-PLA nano-objects and blood proteins in human plasma are studied using isothermal calorimetry.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
1521-3935
Volume of the periodical
224
Issue of the periodical within the volume
23
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2300271
UT code for WoS article
001091321100001
EID of the result in the Scopus database
2-s2.0-85174948309