Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00581912" target="_blank" >RIV/61389013:_____/24:00581912 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14160/24:00135402 RIV/00027162:_____/24:N0000008

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0268005X23012390?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0268005X23012390?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.foodhyd.2023.109693" target="_blank" >10.1016/j.foodhyd.2023.109693</a>

Result language

angličtina

Original language name

Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+ and Zn2+ ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics

Original language description

Alginate gels are outstanding biomaterials widely applicable in food and pharmaceutical industries. This contribution provides comprehensive insight into the design of advanced hybrid alginate/pectin co-networks double crosslinked by Ca2+/Zn2+ ions encapsulating self-emulsifying systems (SES). The tunable mucoadhesive properties, structural stability, integrity, dissolution profiles, and enhanced in-vivo bioavailability make the synthesized hybrid systems ideal vehicles for the delivery of lipophilic phytotherapeutics, allowing the long-term site-specific treatment of intestinal inflammation. This work also provides a thorough understanding of the structure-property relationships of alginate-pectin gels at the atomic resolution level. It was found out that SES molecules form well-distributed, phase-separated microparticles that interact with the polysaccharide matrix through a well-defined interface. The hybrid alginate-pectin gel is highly cross-linked, with both types of polysaccharides participating in the network formation. The observed surface interactions of SES droplets increase the intrinsic mobility of the network. The plasticizing effect can be regulated by the amount of pectin macromolecules, whose interaction with alginate chains enables a strengthening of the polysaccharide network. Overall, the domain-like architecture of hybrid alginate-pectin gels synthesized by external ionic gelation is revealed, the key structural motifs responsible for their properties are discovered, and the pathways allowing their regulation are identified. Biological in-vivo tests then confirmed positive effects of the synthesized systems in living organisms. The strategy presented thus offers a new perspective for the rational design of alginate-based materials for the microencapsulation of bioactive compounds for advanced orally administered delivery systems or controlled-release decontaminators applicable in the food and nutraceutical processing industries.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/GA22-03187S" target="_blank" >GA22-03187S: Rational Design of Polysaccharide‐based Particulate Systems for the Delivery of Mucosal Therapeutics with Broad Spectrum of Biological Activities</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food Hydrocolloids

ISSN

0268-005X

e-ISSN

1873-7137

Volume of the periodical

150

Issue of the periodical within the volume

May

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

109693

UT code for WoS article

001154019500001

EID of the result in the Scopus database

2-s2.0-85182024378