Structural optimization of diblock polymers that undergo thermo-responsive nanoparticle self-assembly for intravitreal drug delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00585472" target="_blank" >RIV/61389013:_____/24:00585472 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S001430572400315X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S001430572400315X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2024.113054" target="_blank" >10.1016/j.eurpolymj.2024.113054</a>
Alternative languages
Result language
angličtina
Original language name
Structural optimization of diblock polymers that undergo thermo-responsive nanoparticle self-assembly for intravitreal drug delivery
Original language description
Certain diseases of the eye require frequent intravitreal injections to sustain active drug concentrations due to the limited volume (≤50 µL) of solution that can be administered each injection. Drug delivery systems have been evaluated to reduce dosing frequency but achieving (i) high concentrations with low viscosity (<100 cP) and (ii) narrow range of particle size (∼20–70 nm) to prolong drug activity without affecting vision remain major challenges. To address these challenges, we synthesized a combinatorial library of thermo-responsive polymer-drug conjugates with diblock architecture and assessed how various parameters (monomer unit composition, block length, drug density and attachment site) affect properties impacting ocular injection suitability. Our screens identified a lead composition, p[(N-isopropylmethacyrlamide)–co-(N-benzylmethacrylamide)]-b-p(N-(2-hydroxypropyl)methacrylamide) with 20 mol% N-benzylmethacrylamide (p[(NIPMAM)–co-(BnMAM)]-b-p(HPMA)), that exists as unimers at room temperature that can be highly concentrated (200 mg/mL) and injected at low viscosity but self-assemble into 20–70 nm particles upon injection into vitreous humor at body temperature. Furthermore, covalent attachment of representative small molecule, peptide- and protein-based drugs had minimal to no impact on thermoresponsive and hydrodynamic behavior highlighting the versatility of the lead composition as a platform for delivering a broad range of different drug molecules.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Polymer Journal
ISSN
0014-3057
e-ISSN
1873-1945
Volume of the periodical
212
Issue of the periodical within the volume
27 May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
113054
UT code for WoS article
001295248600001
EID of the result in the Scopus database
2-s2.0-85190897718