Fully synthetic, tunable poly(alpha-amino acids) as the base of bioinks curable by visible light

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00585861" target="_blank" >RIV/61389013:_____/24:00585861 - isvavai.cz</a>
Result on the web
<a href="https://iopscience.iop.org/article/10.1088/1748-605X/ad3f62" target="_blank" >https://iopscience.iop.org/article/10.1088/1748-605X/ad3f62</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1748-605X/ad3f62" target="_blank" >10.1088/1748-605X/ad3f62</a>

Result language
angličtina
Original language name
Fully synthetic, tunable poly(alpha-amino acids) as the base of bioinks curable by visible light
Original language description
Bioinks play a crucial role in tissue engineering, influencing mechanical and chemical properties of the printed scaffold as well as the behavior of encapsulated cells. Recently, there has been a shift from animal origin materials to their synthetic alternatives. In this context, we present here bioinks based on fully synthetic and biodegradable poly(α,L-amino acids) (PolyAA) as an alternative to animal-based gelatin methacrylate (Gel-Ma) bioinks. Additionally, we first reported the possibility of the visible light photoinitiated incorporation of the bifunctional cell adhesive RGD peptide into the PolyAA hydrogel matrix. The obtained hydrogels are shown to be cytocompatible, and their mechanical properties closely resemble those of gelatin methacrylate-based scaffolds. Moreover, combining the unique properties of PolyAA-based bioinks, the photocrosslinking strategy, and the use of droplet-based printing allows the printing of constructs with high shape fidelity and structural integrity from low-viscosity bioinks without using any sacrificial components. Overall, presented PolyAA-based materials are a promising and versatile toolbox that extends the range of bioinks for droplet bioprinting.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/GA21-06524S" target="_blank" >GA21-06524S: Xeno-free enzymatically degradable polymer materials for 4D bioprinting</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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