Cross-linked gelatine by modified dextran as a potential bioink prepared by a simple and non-toxic process

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28140%2F22%3A63550758" target="_blank" >RIV/70883521:28140/22:63550758 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/22:63550758 RIV/70883521:28110/22:63550758

Result on the web

<a href="https://www.mdpi.com/2073-4360/14/3/391" target="_blank" >https://www.mdpi.com/2073-4360/14/3/391</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym14030391" target="_blank" >10.3390/polym14030391</a>

Result language

angličtina

Original language name

Cross-linked gelatine by modified dextran as a potential bioink prepared by a simple and non-toxic process

Original language description

Essential features of well-designed materials intended for 3D bioprinting via microex-trusion are the appropriate rheological behavior and cell-friendly environment. Despite the rapid development, few materials are utilizable as bioinks. The aim of our work was to design a novel cytocompatible material facilitating extrusion-based 3D printing while maintaining a relatively simple and straightforward preparation process without the need for harsh chemicals or radiation. Specifically, hydrogels were prepared from gelatines coming from three sources—bovine, rabbit, and chicken—cross-linked by dextran polyaldehyde. The influence of dextran concentration on the properties of hydrogels was studied. Rheological measurements not only confirmed the strong shear-thinning behavior of prepared inks but were also used for capturing cross-linking reaction kinetics and demonstrated quick achievement of gelation point (in most cases &lt; 3 min). Their viscoelastic properties allowed satisfactory extrusion, forming a self-supported multi-layered uniformly porous structure. All gelatin-based hydrogels were non-cytototoxic. Homogeneous cells distribution within the printed scaffold was confirmed by fluorescence confocal microscopy. In addition, no disruption of cells structure was observed. The results demonstrate the great potential of the presented hydrogels for applications related to 3D bioprinting.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymers

ISSN

2073-4360

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

nestrankovano

UT code for WoS article

000754557300001

EID of the result in the Scopus database

2-s2.0-85123200312