Bio-responsive polymers for dual 31P/19F-magnetic resonance to detect reactive oxygen species in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00598010" target="_blank" >RIV/61389013:_____/24:00598010 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/24:00085028 RIV/00216208:11110/24:10483260
Result on the web
<a href="https://www.nature.com/articles/s43246-024-00623-z" target="_blank" >https://www.nature.com/articles/s43246-024-00623-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s43246-024-00623-z" target="_blank" >10.1038/s43246-024-00623-z</a>
Alternative languages
Result language
angličtina
Original language name
Bio-responsive polymers for dual 31P/19F-magnetic resonance to detect reactive oxygen species in vivo
Original language description
Biocompatible metal-free agents are emerging as a promising alternative to commercial magnetic resonance (MR) contrast agents, but there is an additional need for novel probes with enhanced responsiveness in preclinical MR testing to effectively target diverse pathological conditions. To address this, we develop hydrophilic phospho-/fluoropolymers as dual MR probes. Incorporating thiophosphoester groups (P = S) into the polymer structure produces a distinct chemical shift (~59 ppm) in phosphorus MR (31P-MR), reducing biological signals interference. Reactive oxygen species (ROS) oxidize the P = S groups, causing a detectable shift in 31P-MR, enabling precise localization of ROS, abundant in inflammation and cancer. To enhance this capability, bioinert trifluoromethyl groups (CF3) are added, creating a “hotspot” for fluorine MR (19F-MR), aiding in vivo localization. Both in vitro and in vivo testing demonstrate the probe’s high specificity and responsiveness, underscoring its potential as a sensitive ROS sensor and dual MR-traceable tool in cancer research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Communications Materials
ISSN
2662-4443
e-ISSN
2662-4443
Volume of the periodical
5
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
178
UT code for WoS article
001307836000001
EID of the result in the Scopus database
2-s2.0-85203260497