Surface-engineered core-shell upconversion nanoparticles for effective hypericin delivery and multimodal imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00617975" target="_blank" >RIV/61389013:_____/25:00617975 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr05348f" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr05348f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D4NR05348F" target="_blank" >10.1039/D4NR05348F</a>
Alternative languages
Result language
angličtina
Original language name
Surface-engineered core-shell upconversion nanoparticles for effective hypericin delivery and multimodal imaging
Original language description
Early diagnosis and treatment of cancer is rapidly advancing thanks to the development of nanotechnology. Here, upconversion nanoparticles (UCNPs) are particularly promising as they are finding a wide range of applications in drug delivery and tumor imaging. In this report, a novel UCNP-based transport system is proposed for the delivery of the hypericin (Hyp) photosensitizer into malignant tumors. Core–shell NaYF4:Yb3+,Er3+@NaYF4:Nd3+ UCNPs were prepared by thermal decomposition and coated with poly(N,N-dimethylacrylamide-co-2-aminoethyl acrylate)-alendronate [P(DMA-AEA)-Ale], which endowed them with colloidal and chemical stability, finally, Hyp was conjugated. Internalization of CS-UCNP@P(DMA-AEA)-Ale-Hyp nanoparticles by Jurkat cells was successfully validated by multimodal imaging using a microstructural chamber, upconversion luminescence, and Raman microspectroscopy. After irradiation at 590 nm, CS-UCNP@P(DMA-AEA)-Ale-Hyp nanoparticles provided a markedly more effective photodynamic effect than Hyp alone at identical Hyp concentrations due to apoptosis as confirmed by caspase-3 activation. MTT assays showed that Hyp-free nanoparticles were non-cytotoxic, whereas CS-UCNP@P(DMA-AEA)-Ale-Hyp particles significantly reduced cell viability after irradiation. Considering that Hyp release from the nanoparticles was higher in the acidic environment typical of tumors compared to physiological ones, UCNP@P(DMA-AEA)-Ale-Hyp particles are a suitable candidate for future in vivo applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/GA24-10125S" target="_blank" >GA24-10125S: Surface-engineered upconversion nanoparticles for quantitative diagnostics of pancreatic β-cells in diabetology by MRI, fluorescence and microscopy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale
ISSN
2040-3364
e-ISSN
2040-3372
Volume of the periodical
17
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
5838-5857
UT code for WoS article
001412816000001
EID of the result in the Scopus database
2-s2.0-85217096006