Theranostic verteporfin-conjugated upconversion nanoparticles for cancer treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00641094" target="_blank" >RIV/61389013:_____/25:00641094 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10506001
Result on the web
<a href="https://www.mdpi.com/2079-4991/15/22/1690" target="_blank" >https://www.mdpi.com/2079-4991/15/22/1690</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nano15221690" target="_blank" >10.3390/nano15221690</a>
Alternative languages
Result language
angličtina
Original language name
Theranostic verteporfin-conjugated upconversion nanoparticles for cancer treatment
Original language description
Photodynamic therapy (PDT) is a highly selective, clinically approved, minimally invasive technique that effectively eliminates cancer cells. Its effectiveness is limited by poor light penetration into tissue and the hydrophobic nature of photosensitizers, highlighting the need for new approaches to treatment. Here, a theranostic upconversion nanoplatform, consisting of a NaYF4:Yb,Er,Tm,Fe core and a NaHoF4 shell codoped with Yb, Nd, Gd and Tb ions, was designed to enhance PDT outcomes by integrating multi-wavelength upconversion luminescence, T2-weighted magnetic resonance imaging (MRI) and PDT. The synthesized core–shell upconversion nanoparticles (CS-UCNPs) were coated with new verteporfin (VP)-conjugated alendronate-terminated poly(N,N-dimethylacrylamide-co-2-aminoethyl acrylate) [Ale-P(DMA-AEA)] grafted with poly(ethylene glycol) (PEG). Under 980 nm NIR irradiation, CS-UCNP@Ale-P(DMA-AEA)-PEG-VP nanoparticles generated reactive oxygen species (ROS) due to the efficient energy transfer between CS-UCNPs and VP. In a pilot preclinical study, intratumoral administration of nanoparticle conjugates to mice, followed by exposure to NIR light, induced necrosis of pancreatic tumor and suppressed its growth.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomaterials
ISSN
2079-4991
e-ISSN
2079-4991
Volume of the periodical
15
Issue of the periodical within the volume
22
Country of publishing house
CH - SWITZERLAND
Number of pages
24
Pages from-to
1690
UT code for WoS article
001624253800001
EID of the result in the Scopus database
2-s2.0-105022896992