Tailoring polyester-based diblock copolymers for boron-enhanced drug delivery: synthesis, kinetics, and nanoparticle characterization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00617978" target="_blank" >RIV/61389013:_____/25:00617978 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10500080
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/py/d4py01363h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/py/d4py01363h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D4PY01363H" target="_blank" >10.1039/D4PY01363H</a>
Alternative languages
Result language
angličtina
Original language name
Tailoring polyester-based diblock copolymers for boron-enhanced drug delivery: synthesis, kinetics, and nanoparticle characterization
Original language description
Here, we present the synthesis of diblock copolymers of poly(ethylene glycol) methyl ether-b-poly(ε-caprolactone) (mPEG-b-PCL) with prop-2-ynyl (propargyl) substituents on ε-caprolactone (ε-CL) units. The copolymerization of ε-CL with its propargylated derivative initiated by mPEG, followed by a thiol–yne click reaction with 1-thioglycerol, results in copolymers featuring vicinal diols capable of reversibly binding boronic acid derivatives. Detailed kinetic experiments were conducted to monitor the homo- and copolymerization of ε-CL with 7-(prop-2-ynyl)oxepan-2-one. By analyzing the kinetic data, we calculated the copolymerization parameters and mapped the composition profile of the resulting copolymers. The resulting gradient copolymers exhibited a lightly tapered composition profile, with an increase in ε-CL consumption at higher conversions where the more reactive 7-(prop-2-ynyl)oxepan-2-one is almost depleted. These findings were further validated through quantum chemical calculations, providing insights into the precise structure and composition of the copolymers. Characterization of the self-assembled nanoparticles was performed using static and dynamic light scattering, and their morphology was visualized via conventional and cryogenic transmission electron microscopy, confirming the formation of small, homogeneous spherical micelles. To demonstrate their potential in drug delivery, we combined a model drug consisting of a phenylboronic acid-conjugated metallacarborane cluster with diblock copolymer, utilizing reversible bonding between diols and phenylboronic acid and investigated the impact of drug loading on nanoparticle properties. Our comprehensive study underscores the importance of precise synthesis and structural prediction in the development of biodegradable diblock copolymers, offering valuable insights into their synthesis, kinetic behavior, and nanoscale assembly for advanced drug delivery applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GF21-20008K" target="_blank" >GF21-20008K: Metallacarboranes as unique platform for fabrication of functional nano-assemblies and polymer materials</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Chemistry
ISSN
1759-9954
e-ISSN
1759-9962
Volume of the periodical
16
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
1217-1230
UT code for WoS article
001415287800001
EID of the result in the Scopus database
2-s2.0-86000436563