Mild-temperature synthesis of gold colloids with unique features mediated by polymers of biomedical interest
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00635954" target="_blank" >RIV/61389013:_____/25:00635954 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsomega.5c01123" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.5c01123</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.5c01123" target="_blank" >10.1021/acsomega.5c01123</a>
Alternative languages
Result language
angličtina
Original language name
Mild-temperature synthesis of gold colloids with unique features mediated by polymers of biomedical interest
Original language description
Well-defined gold nanoparticles (AuNPs) are accessible via simple synthetic methods, and their surface chemistry stands as a key factor in determining applications in the biomedical field. While macromolecules featuring amino groups are already known to successfully mediate the formation of stable gold colloids in one-pot, two-reactant, no workup reactions in aqueous media, we herein report the discovery that, under mild reaction temperatures, polymers of outstanding biomedical interest not only can play the simultaneous role of reducing and capping agent but also lead to particulate systems with unique features. From a library of samples that included branched polyethylenimine (BPEI), poly(l-lysine) (PLL), bovine serum albumin (BSA), poly(2-methyl-2-oxazoline) (PMeOx), poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA), and amine-functionalized poly(N-(2-hydroxypropyl)methacrylamide-co-N-(3-aminopropyl)methacrylamide) P(HPMA-co-APMA), we found that PHPMA end-functionalized with nitrile motifs generate spherical and stable AuNPs@PHPMA of very small size (diameter of ∼2.4 nm), as underlined by imaging experiments. Cell viability experiments indicated exceptionally good biocompatibility up to very high numerical particle concentrations as compared to the other systems. The reduced size imparted to the AuNPs@PHPMA outstanding catalytic properties (no induction time and high reaction rate constant for the hydrogenation of p-nitrophenol) and antimicrobial activity (total antibacterial activity against Escherichia coli and dose-dependent antibacterial activity against Staphylococcus aureus). The introduction of primary amine groups (13.4 mol %) of higher nucleophilicity known to work better for AuNP synthesis makes these unique features disappear, as evidenced for P(HPMA-co-APMA). The other systems yielded 6–28 nm particles whose properties reflected both the size of the metallic core and chemical nature and conformation of the capping agent. These findings point to novel applications of PHPMA polymers worthy of further development, especially in light of their excellent water solubility and biocompatibility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
2470-1343
Volume of the periodical
10
Issue of the periodical within the volume
21
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
21701-21714
UT code for WoS article
001493300500001
EID of the result in the Scopus database
2-s2.0-105005803598