Well-defined poly(HPMAm) brushes via surface-initiated RAFT polymerization, a mixed-chain transfer agent (CTA) approach
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637489" target="_blank" >RIV/61389013:_____/25:00637489 - isvavai.cz</a>
Result on the web
<a href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500196" target="_blank" >https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500196</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/admi.202500196" target="_blank" >10.1002/admi.202500196</a>
Alternative languages
Result language
angličtina
Original language name
Well-defined poly(HPMAm) brushes via surface-initiated RAFT polymerization, a mixed-chain transfer agent (CTA) approach
Original language description
Over three decades, efforts to prevent non-specific protein adsorption on surfaces have improved. However, developing well-defined antifouling coatings remains a challenge in biomaterials research. In this study, a rapid and straightforward protocol relying on surface-initiated reversible addition-fragmentation chain-transfer (RAFT) polymerization (S-RAFT) is demonstrated to fabricate poly(N-(2-hydroxypropyl methacrylamide), poly(HPMAm)) brushes employing a mixed-chain transfer agent (CTA) approach. By systematically evaluating different combinations of surface-tethered and free CTAs, it is demonstrated that the simultaneous use of structurally distinct CTA classes, dithiobenzoate (DTB) and trithiocarbonate (TTC), enhances polymerization control and brush growth rates. The conditions enable the fabrication of poly(HPMAm) brushes exceeding 70 nm in thickness within only 4 h at 50 °C. Spectroscopic ellipsometry confirmed that the mixed-CTA approach significantly outperforms single-CTA systems, yielding higher polymerization efficiency and greater brush thickness. Additionally, size exclusion chromatography (SEC) confirmed that the solution-born polymers exhibited narrow dispersity (Ð = 1.05–1.15), ensuring well-defined polymer structures. The findings highlight the advantages of combining different CTAs in a single polymerization system, leading to a more efficient and scalable method for fabricating antifouling poly(HPMAm) coatings. This approach offers a significant potential for biomedical applications, including biosensors, blood-contacting devices, and implantable materials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Materials Interfaces
ISSN
2196-7350
e-ISSN
2196-7350
Volume of the periodical
12
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2500196
UT code for WoS article
001493277700001
EID of the result in the Scopus database
2-s2.0-105006618523