Effect of side groups on the surface parameters and antifouling properties of poly(N-alkyl acrylamide)-coated surfaces
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637795" target="_blank" >RIV/61389013:_____/25:00637795 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10500111
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/macp.202400481" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/macp.202400481</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.202400481" target="_blank" >10.1002/macp.202400481</a>
Alternative languages
Result language
angličtina
Original language name
Effect of side groups on the surface parameters and antifouling properties of poly(N-alkyl acrylamide)-coated surfaces
Original language description
Understanding the origins of antifouling properties in polymer materials is essential for improving their biocompatibility. In this work, the effect of side groups in poly(N-alkyl acrylamide)s on their resistance to non-specific interactions with blood proteins is studied. Using reversible addition-fragmentation chain transfer (RAFT) polymerization protocol, a library of acrylamide-based polymers is synthesized, including poly((N-propyl)acrylamide) (pPAM), poly((N-ethyl)acrylamide) (pEAM), poly(N-(2-fluoroethyl)acrylamide) (pFEAM) and poly(N-(2-hydroxyethyl)acrylamide) (pHEAM), with four distinct chain lengths, i.e. degrees of polymerization (DP = 25, 50, 75, and 100). The polymer chains are attached to gold substrates under the most widely used “grafting to” approach through the trithiocarbonate chain end groups. The physical properties of the resulting polymer coatings are studied and evaluated their antifouling properties against blood plasma. While the of pPAM and pEAM reduced the fouling to a certain extent, semi-fluorinated pFEAM and pHEAM coatings showed improved fouling resistance with increasing DP and enhanced brush-like character. Notably, pFEAM and pHEAM coatings of nominal DP = 100 manage to reduce the fouling by more than 90% when compared to bare gold surfaces. These findings highlight the critical role of polymer side groups and chain length in designing antifouling coatings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
1521-3935
Volume of the periodical
226
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
70001
UT code for WoS article
001483301900001
EID of the result in the Scopus database
2-s2.0-105004689871