Designing magnetic graphene oxide-polymer nanocomposites for pH-responsive passive targeting of hydrophobic anticancer drug 5-fluorouracil for breast cancer therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637798" target="_blank" >RIV/61389013:_____/25:00637798 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0378517325007938?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517325007938?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2025.125956" target="_blank" >10.1016/j.ijpharm.2025.125956</a>
Alternative languages
Result language
angličtina
Original language name
Designing magnetic graphene oxide-polymer nanocomposites for pH-responsive passive targeting of hydrophobic anticancer drug 5-fluorouracil for breast cancer therapy
Original language description
In this study, we synthesized magnetic graphene oxide nanoparticles functionalized with polyvinyl alcohol (GO-PVA-Fe3O4) for effective delivery of anticancer drug and its cytotoxic potential against human breast cancer cells MDAMB. Initially, GO was synthesized using a modified Hummer’s method. Subsequently, the GO was functionalized with the biocompatible polymer PVA to enhance its aqueous stability and surface reactivity. Magnetic nanoparticles (Fe3O4) were then grafted onto the PVA-functionalized GO via a chemical co-precipitation method, resulting in the formation of a stable magnetic nanocomposite. The anticancer drug 5-fluorouracil (5FU) was loaded onto the surface of the nanocarrier by non-covalent interaction. The developed nanocomposite (GO-PVA-Fe3O4-5FU) showed high drug loading capacity of 14.17 % mg mg−1 along with pH-responsive drug release of anticancer drug 5FU. 5-FU has demonstrated around 30.40 % drug release which is about 2.5 times higher than the drug release at pH 7.4 that demonstrated improved and passive targeted drug release at cancer microenvironment. Cellular cytotoxicity of the developed nanocarrier with the drug showed biocompatibility and higher cytotoxicity against MDAMB with an IC50 value of 23.65 ± 3.72 µg/mL as compared to the nanocarrier without drug loading. Therefore, the obtained results demonstrate potential of the synthesized nanocarriers as effective platforms for drug delivery. Overall, the GO-based magnetic nanocomposites exhibited promising characteristics for passive targeted drug delivery applications, offering improved biocompatibility, pH-responsive controlled release, and suitability for prospective cancer therapeutics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Volume of the periodical
682
Issue of the periodical within the volume
15 September
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
125956
UT code for WoS article
001540280500001
EID of the result in the Scopus database
2-s2.0-105010692656