Electrospun PCL mats modified with magnetic nanoparticles and tannic acid with antibacterial and possible antiosteosarcoma activity for bone tissue engineering and cancer treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637802" target="_blank" >RIV/61389013:_____/25:00637802 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/25:00637802 RIV/44555601:13440/25:43899209 RIV/00216208:11310/25:10515588
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c00116" target="_blank" >https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c00116</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsbiomaterials.5c00116" target="_blank" >10.1021/acsbiomaterials.5c00116</a>
Alternative languages
Result language
angličtina
Original language name
Electrospun PCL mats modified with magnetic nanoparticles and tannic acid with antibacterial and possible antiosteosarcoma activity for bone tissue engineering and cancer treatment
Original language description
Modifying scaffolds with agents that at the same time positively influence osteogenic cells and have a negative impact on cancerous growth, is a promising solution for patients with bone tissue defects following tumor excision. Such materials may not only boost tissue regeneration but also limit the risk of cancer reoccurrence. In our study, we developed novel bifunctional scaffolds containing magnetic nanoparticles grafted with PCL (MNP@PCL) and tannic acid (TA), which may be directed to support normal bone cells and suppress osteosarcoma cells. First, MNPs were postsynthetically surface-modified, by grafting poly(ε-caprolactone) (PCL) from the surface via ring opening polymerization of ε-caprolactone, to provide their uniform distribution within the polymer matrix. Then, fiber mats containing a fixed amount of MNPs (2 wt %) and increasing content of TA (0, 1, 5, and 10 wt %) were prepared by electrospinning method. Both MNP@PCL and TA decreased polymer crystallinity. The interaction between the MNPs and TA significantly influenced the mat morphology, thermal properties, and initial hydrolytic performance. The most intensive TA release was observed mainly within first 6 h of incubation, and it was 3.5-fold higher (ca. 0.02 mg of TA/per mg of mat) for mfPCL@TA-10 compared to mfPCL@TA-5. Moreover, TA-containing magnetic mats suppressed the metabolic activity of osteosarcoma cells. They also demonstrated enhanced antimicrobial properties against the bacteria typically accompanying orthopedic complications, reducing the population of Gram-positive bacteria by more than 90% compared to the neat PCL mat. This proves the high potential of these materials for combining cancer treatment with bone tissue engineering.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA20-07015S" target="_blank" >GA20-07015S: Magnetic Composite Materials for Non-Invasive Cell Stimulation in Tissue Engineering</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Biomaterials Science & Engineering
ISSN
2373-9878
e-ISSN
2373-9878
Volume of the periodical
11
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
4315-4330
UT code for WoS article
001517659500001
EID of the result in the Scopus database
2-s2.0-105009257738