Lanthanide-based UCNPs: toxicity evaluation and interaction of ultrasmall core vs. core-shell nanoparticles with cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00639400" target="_blank" >RIV/61389013:_____/25:00639400 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/25:00639400

Result on the web

<a href="https://pubs.rsc.org/en/content/articlelanding/2025/ma/d5ma00542f" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/ma/d5ma00542f</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D5MA00542F" target="_blank" >10.1039/D5MA00542F</a>

Result language

angličtina

Original language name

Lanthanide-based UCNPs: toxicity evaluation and interaction of ultrasmall core vs. core-shell nanoparticles with cells

Original language description

We describe a new concept for preparation of ultrasmall NaYF4:Yb,Er upconversion nanoparticles (UCNPs) with a diameter of 7 nm, depending on the amount of water added in the polymerization mixture, which affects the nucleation and growth of the particles. The morphology and structure of the nanoparticles were thoroughly characterized both in the dried state (TEM including elemental analysis and electron diffraction) and in solution (small and wide-angle X-ray scattering and dynamic light scattering). A thick NaYF4 shell was subsequently introduced onto the particles, which significantly increased the luminescence by minimizing surface quenching effects and passivating the core from the surrounding environment. To make the particles dispersible in the aqueous environment natural for biological applications, they were coated with a ∼6 nm thick hydrophilic silica layer. This increased the size of core and core–shell UCNPs to 20 and ∼50 nm. All the developed particles exhibited non-cytotoxicity tested in insulinoma INS-1E cells. The upconversion luminescence of these nanoparticles incubated with INS-1E cells showed a similar pattern to that of the particles themselves. The small biocompatible UCNPs developed in this study are promising candidates for non-invasive and non-destructive applications in bioimaging. Thanks to their advantageous properties, i.e., small size, adjustable optical properties and ability to interact with and easily penetrate cells, they are suitable for future use in platforms for targeted drug delivery and advanced diagnostic technologies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/GA24-10125S" target="_blank" >GA24-10125S: Surface-engineered upconversion nanoparticles for quantitative diagnostics of pancreatic β-cells in diabetology by MRI, fluorescence and microscopy</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials Advances

ISSN

2633-5409

e-ISSN

2633-5409

Volume of the periodical

6

Issue of the periodical within the volume

19

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

6907-6918

UT code for WoS article

001559307300001

EID of the result in the Scopus database

2-s2.0-105017614676