Biocompatible interpenetrating network hydrogels with dually cross-linked polyol
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00639877" target="_blank" >RIV/61389013:_____/25:00639877 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2073-4360/17/20/2737" target="_blank" >https://www.mdpi.com/2073-4360/17/20/2737</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/polym17202737" target="_blank" >10.3390/polym17202737</a>
Alternative languages
Result language
angličtina
Original language name
Biocompatible interpenetrating network hydrogels with dually cross-linked polyol
Original language description
Modern tissue regeneration strategies rely on soft biocompatible materials with adequate mechanical properties to support the growing tissues. Polymer hydrogels have been shown to be available for this purpose, as their mechanical properties can be controllably tuned. In this work, we introduce interpenetrating polymer networks (IPN) hydrogels with improved elasticity due to a dual cross-linking mechanism in one of the networks. The proposed hydrogels contain entangled polymer networks of covalently cross-linked poly(ethylene glycol) methacrylate/diacrylate (PEGMA/PEGDA) and poly(vinyl alcohol) (PVA) with two types of physical cross-links—microcrystallites and tannic acid (TA). Rheological measurements demonstrate the synergistic enhancement of the elastic modulus of the single PEGMA/PEGDA network just upon the addition of PVA, since the entanglements between the two components are formed. Moreover, the mechanical properties of IPNs can be independently tuned by varying the PEGMA/PEGDA ratio and the concentration of PVA. Subsequent freezing–thawing and immersion in the TA solution of IPN hydrogels further increase the elasticity because of the formation of the microcrystallites and OH-bonds with TA in the PVA network, as evidenced by X-ray diffraction and ATR FTIR-spectroscopy, respectively. Structural analysis by cryogenic scanning electron microscopy and light microscopy reveals a microphase-separated morphology of the hydrogels. It promotes extensive contact between PVA macromolecules, but nevertheless enables the formation of a 3D network. Such structural arrangement results in the enhanced mechanical performance of the proposed hydrogels, highlighting their potential use for tissue engineering.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymers
ISSN
2073-4360
e-ISSN
2073-4360
Volume of the periodical
17
Issue of the periodical within the volume
20
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
2737
UT code for WoS article
001601535500001
EID of the result in the Scopus database
2-s2.0-105020158201