Hybrid thermoresponsive kappa-carrageenan-based polymer nanogels respond differently to mono- and divalent metal cations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00641087" target="_blank" >RIV/61389013:_____/25:00641087 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0167732225019592?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167732225019592?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2025.128782" target="_blank" >10.1016/j.molliq.2025.128782</a>

Result language

angličtina

Original language name

Hybrid thermoresponsive kappa-carrageenan-based polymer nanogels respond differently to mono- and divalent metal cations

Original language description

We investigated the stimuli-responsive behavior of hybrid κ-carrageenan-based polymers grafted with poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline) (POX), focusing on how these polymers respond simultaneously to mono- and divalent metal cations as well as changes in temperature. The aim of this study was to explore their potential for biological and radiopharmaceutical applications, where their responsiveness to specific stimuli is crucial. To achieve this, we used dynamic light scattering and small-angle X-ray scattering as key methodologies. We examined how the length and density of POX grafts influenced the polymers' solubility transitions and formation of nanogel clusters. Our results showed that shorter POX grafts resulted in smaller nanogel clusters, with graft length having a more significant effect on particle size compared to graft density. In addition, polymers with shorter grafts exhibited a higher temperature at which solubility changes occurred. The study also examines the effects of metal ions (Na+, K+, Rb+, Ca2+, and Sr2+) on the nanogel structure. We found that the fractal dimension of the clusters decreased for K+ and Ca2+ when the POX groups lost their solubility above the lower critical solution temperature (LCST), whereas it remained stable for Na+. Our findings highlight the complex molecular interactions and stimulus-responsivity cross-talks that govern the stimulus-responsive behavior of these hybrid copolymers. Understanding these interactions opens up avenues for future applications.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

1873-3166

Volume of the periodical

440

Issue of the periodical within the volume

15 December

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

128782

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-105021039268