Effect of shock waves combined with cytostatics on the growths of tumors in vivo

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389021%3A_____%2F19%3A00555853" target="_blank" >RIV/61389021:_____/19:00555853 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10410951

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/2019/68_S475.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2019/68_S475.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/PHYSIOLRES.934386" target="_blank" >10.33549/PHYSIOLRES.934386</a>

Result language

angličtina

Original language name

Effect of shock waves combined with cytostatics on the growths of tumors in vivo

Original language description

Based on their field of application, the physical parameters of shock waves differ. Experiments referred to in this article used tandem shock waves generated on the surface of a composite anode. There, individual pores of the anode produce multichannel discharges. The composite anode may have a variety of shapes, which, consequently, influence the arrangement of the entire apparatus and the area of their application. Experiments referred to in this article utilise an anode divided into two parts that generated tandem shock waves. The previously conducted experiments have clearly shown that the effect of a tandem shock wave can be very well localized in the focal area, causing necrosis and apoptosis of the tumor cells, and enhancing the effect of cytostatics. This study investigated the effect of tandem shock waves with concomitantly administered cytostatics. We conducted our experiments on Lewis rats. The rats were injected with syngeneic sarcoma tumor cells intradermally and caudally on both the right and left sides. The highest rate of tumor growth inhibition was observed in the cisplatin-treated group that was subsequently treated with shock waves. The effect of shock waves on cell membranes is well described as they increase their permeability due to sonodynamic effect induced by cavitation. The results of experiments referred to in this article conducted in vivo in experimental animals enable us to note that the shock wave increases the effect of chemotherapy administered.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Volume of the periodical

68

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

475-481

UT code for WoS article

000529413800014

EID of the result in the Scopus database

2-s2.0-85081116078